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首页> 外文期刊>International journal of molecular imaging >Demonstrating Intertumoural Differences in Vascular-MetabolicPhenotype with Dynamic Contrast-Enhanced CT-PET
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Demonstrating Intertumoural Differences in Vascular-MetabolicPhenotype with Dynamic Contrast-Enhanced CT-PET

机译：用动态对比度增强的CT-PET证明血管代谢表型的肿瘤间差异

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Purpose. To assess whether the differences in vascular-metabolic relationships between lymphoma masses and colorectal liver metastases predicted from previous histopathological studies can be demonstrated by dynamic contrast-enhanced CT (DCE-CT) combined with fluorodeoxyglucose positron emission tomography (FDG-PET).Methods. DCE-CT and FDG-PET studies were drawn from an imaging archive for patients with either lymphoma masses (n=11) or hepatic metastases from colorectal cancer (CRM:n=12). Tumour vascularity was assessed using DCE-CT measurements of perfusion. Tumour glucose metabolism was expressed as the mean FDG Standardised Uptake Value (SUVFDG). The relationship between metabolism and vascularity in each group was assessed fromSUVFDG/perfusion ratios and Pearson correlation coefficients.Results. AnSUVFDGthreshold of 3.0 was used to designate lymphoma masses as active (AL,n=6) or inactive lymphoma (IL,n=5). Tumour perfusion was significantly higher in AL (0.65 mL/min/mL) than CRM (0.37 mL/min/mL:P=.031) despite similarSUVFDG(5.05 and 5.33, resp.). AL demonstrated higher perfusion values than IL (0.24 mL/min/mL:P=.006).SUVFDG/perfusion was significantly higher in CRM (15.3 min) than IL (4.2 min,P<.01). There was no correlation betweenSUVFDGand perfusion for any patient group.
机译：目的。为了评估以前的组织病理学研究预测的淋巴瘤肿块与大肠肝转移之间的血管代谢关系差异是否可以通过动态对比增强CT（DCE-CT）结合氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）来证明。 DCE-CT和FDG-PET研究是从影像学档案库中提取的，这些患者患有淋巴瘤肿块（n = 11）或结直肠癌的肝转移（CRM：n = 12）。使用DCE-CT灌注测量评估肿瘤血管。肿瘤葡萄糖代谢表示为平均FDG标准化摄取值（SUVFDG）。通过SUVFDG /灌注比和皮尔逊相关系数评估各组代谢与血管之间的关系。使用3.0的SUVFDG阈值将淋巴瘤肿块指定为活动性（AL，n = 6）或非活动性淋巴瘤（IL，n = 5）。尽管类似的SUVFDG（分别为5.05和5.33），AL中的肿瘤灌注显着高于CRM（0.37μmL/ min / mL：P = .031），高于AL（0.35μmL/ min / mL：P = .031）。 AL的灌注值高于IL（0.24μmL/ min / mL：P = .006）。CRM（15.3μmin）的SUVFDG /灌注显着高于IL（4.2μmin，P <.01）。 SUVFDG与任何患者组的灌注均无相关性。

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