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首页> 外文期刊>International journal of molecular imaging >Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging
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Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging

机译：动态MicroSPECT成像纵向评估正常和自发性高血压大鼠心脏中脂肪酸的代谢

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The goal of this project is to develop radionuclide molecular imaging technologies using a clinical pinhole SPECT/CT scanner to quantify changes in cardiac metabolism using the spontaneously hypertensive rat (SHR) as a model of hypertensive-related pathophysiology. This paper quantitatively compares fatty acid metabolism in hearts of SHR and Wistar-Kyoto normal rats as a function of age and thereby tracks physiological changes associated with the onset and progression of heart failure inthe SHR model. The fatty acid analog,123I-labeled BMIPP, was used in longitudinal metabolic pinhole SPECT imaging studies performed every seven months for 21 months. The uniqueness of this project is the development of techniques for estimating the blood input function from projection data acquired by a slowly rotating camera that is imaging fast circulation and the quantification of the kinetics of123I-BMIPP by fitting compartmental models to the blood and tissue time-activity curves.
机译：该项目的目标是使用临床针孔SPECT / CT扫描仪开发放射性核素分子成像技术，以自发性高血压大鼠（SHR）作为高血压相关病理生理学的模型来量化心脏代谢的变化。本文定量比较了SHR和Wistar-Kyoto正常大鼠心脏中脂肪酸的代谢随年龄的变化，从而在SHR模型中追踪与心力衰竭的发作和进展相关的生理变化。脂肪酸类似物123I标记的BMIPP用于每七个月进行的纵向代谢针孔SPECT成像研究，为期21个月。该项目的独特之处在于开发了一些技术，这些技术可通过由缓慢旋转的摄像机获取的投影数据估算血液输入功能，该摄像机正在对快速循环进行成像，并通过将间隔模型拟合到血液和组织时间来量化123I-BMIPP的动力学，活动曲线。

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