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TowardsIn VivoImaging of Cancer Sialylation

机译:走向癌症唾液酸化的体内成像

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In vivoassessment of tumor glucose catabolism by positron emission tomography (PET) has become a highly valued study in the medical management of cancer. Emerging technologies offer the potential to evaluatein vivoanother aspect of cancer carbohydrate metabolism related to the increased anabolic use of monosaccharides like sialic acid (Sia). Sia is used for the synthesis of sialylated oligosaccharides in the cell surface that in cancer cells are overexpressed and positively associated to malignancy and worse prognosis because of their role in invasion and metastasis. This paper addresses the key points of the different strategies that have been developed to image Sia expressionin vivoand the perspectives to translate it from the bench to the bedside where it would offer the clinician highly valued complementary information on cancer carbohydrate metabolism that is currently unavailablein vivo.
机译:正电子发射断层扫描(PET)在体内评估肿瘤葡萄糖分解代谢已成为癌症医疗管理中的一项非常有价值的研究。新兴技术提供了体内评估与单糖(如唾液酸(Sia))合成代谢使用增加有关的癌症碳水化合物代谢的另一方面的潜力。 Sia用于在细胞表面合成唾液酸化低聚糖,在癌细胞中,唾液酸化低聚糖由于其在侵袭和转移中的作用而过度表达且与恶性肿瘤和预后不良呈正相关。本文讨论了已开发出的用于在体内成像Sia表达的不同策略的关键点,以及将其从实验台转化为床边的观点,这些方法将为临床医生提供目前体内尚无法获得的有关癌症碳水化合物代谢的高度有价值的补充信息。

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