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首页> 外文期刊>International journal of molecular imaging >Reproducible Analysis of Rat Brain PET Studies Using an Additional [18F]NaF Scan and an MR-Based ROI Template
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Reproducible Analysis of Rat Brain PET Studies Using an Additional [18F]NaF Scan and an MR-Based ROI Template

机译：使用附加的[18F] NaF扫描和基于MR的ROI模板对大鼠脑PET研究进行可重复分析

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Background. An important step in the analysis of positron emission tomography (PET) studies of the brain is the definition of regions of interest (ROI). Image coregistration, ROI analysis, and quantification of brain PET data in small animals can be observer dependent. The purpose of this study was to investigate the feasibility of ROI analysis based on a standard MR template and an additional [18F]NaF scan.Methods. [18F]NaF scans of 10 Wistar rats were coregistered with a standard MR template by 3 observers and derived transformation matrices were applied to corresponding [11C]AF150(S) images. Uptake measures were derived for several brain regions delineated using the MR template. Overall agreement between the 3 observers was assessed by interclass correlation coefficients (ICC) of uptake data. In addition, [11C]AF150(S) ROI data were compared withex vivobiodistribution data.Results. For all brain regions, ICC analysis showed excellent agreement between observers. Reproducibility, estimated by calculation of standard deviation of the between-observer differences, was demonstrated by an average of 17% expressed as coefficient of variation. Uptake of [11C]AF150(S) derived from ROI analysis closely matchedex vivobiodistribution data.Conclusions. The proposed method provides a reproducible and tracer-independent method for ROI analysis of rat brain PET data.
机译：背景。分析大脑的正电子发射断层扫描（PET）研究的重要步骤是定义感兴趣区域（ROI）。小动物的图像配准，ROI分析和大脑PET数据的量化可能取决于观察者。这项研究的目的是研究基于标准MR模板和附加的[18F] NaF扫描的ROI分析的可行性。由3位观察者将10只Wistar大鼠的[18F] NaF扫描与标准MR模板共同配准，并将派生的转换矩阵应用于相应的[11C] AF150（S）图像。使用MR模板描绘了几个大脑区域的摄取量度。 3个观察者之间的总体一致性通过摄取数据的类间相关系数（ICC）进行评估。另外，将[11C] AF150（S）ROI数据与离体体内生物分布数据进行了比较。对于所有大脑区域，ICC分析表明观察者之间的一致性很好。通过计算观察者之间差异的标准偏差估算的可重复性由表示为变异系数的平均值为17％证明。从ROI分析得出的[11C] AF150（S）的摄取与体内生物分布数据十分吻合。所提出的方法为大鼠脑PET数据的ROI分析提供了一种可重现且与示踪剂无关的方法。

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