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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Implication of androgen receptor in urinary bladder cancer: a critical mini review
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Implication of androgen receptor in urinary bladder cancer: a critical mini review

机译：雄激素受体在膀胱癌中的意义：一项重要的综述

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Cancer is probably the most dreaded disease of mankind and the bladder cancer is the fifth most common type of cancer worldwide. It is a major cause of cancer morbidity and mortality. From amongst the bladder cancer, the Transitional Cell Carcinoma (TCC) is the most prevalent cancer of the bladder and accounts for 90% of all bladder cancer cases. Despite such a high prevalence, the molecular mechanism involved in the induction of bladder carcinoma and its progression are poorly understood. Tumorigenesis and tumor progression of bladder carcinomas are thought to result from the accumulation of multiple genetic alterations. The Androgen Receptor (AR) gene is located on the q arm of X chromosome (q11-12) and considered as a ligand-inducible transcription factor that regulates target gene expression. The Androgen plays a vital role in the development and maintenance of the normal urinary bladder. The AR is also involved in the development and progression of urinary bladder carcinoma, which is the most common type of carcinoma. Mutation in AR alters the ligand binding ability that may cause the progression and development of bladder cancer. Tumorigenesis and tumor progression are thought to result from changes in the function of hormonal receptor gene. The accumulation of the changes in AR expressions, determines the tumor’s phenotype and ultimately the patient’s clinical outcome. The early detection of which may help in management and prediction, how will it behave and respond to the therapeutic regimen. The present review aimed to study the mechanism and alteration of AR gene that play a vital role in the tumorIgenesis of bladder carcinoma.
机译：癌症可能是人类最可怕的疾病，膀胱癌是全球第五大最常见的癌症。它是癌症发病率和死亡率的主要原因。在膀胱癌中，移行细胞癌（TCC）是最流行的膀胱癌，占所有膀胱癌病例的90％。尽管患病率如此之高，但人们对导致膀胱癌及其进展的分子机制知之甚少。膀胱癌的肿瘤发生和肿瘤进展被认为是由于多种基因改变的积累所致。雄激素受体（AR）基因位于X染色体（q11-12）的q臂上，被视为调节靶基因表达的配体诱导型转录因子。雄激素在正常膀胱的发育和维持中起着至关重要的作用。 AR还参与膀胱癌的发展和进展，膀胱癌是最常见的癌症类型。 AR中的突变会改变配体结合能力，从而导致膀胱癌的发展。肿瘤发生和肿瘤进展被认为是由于激素受体基因功能的改变所致。 AR表达变化的累积决定了肿瘤的表型，最终决定了患者的临床结局。尽早发现可能有助于管理和预测，其表现如何并对治疗方案作出反应。本综述旨在研究在膀胱癌的肿瘤发生中起重要作用的AR基因的机制和改变。

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