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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Association of SNPs in GHSR rs292216 and rs509035 on dietary intake in Indonesian obese female adolescents
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Association of SNPs in GHSR rs292216 and rs509035 on dietary intake in Indonesian obese female adolescents

机译：印尼肥胖女性青少年中GHSR rs292216和rs509035中SNP与饮食摄入的关联

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Background: Obesity has been linked to high dietary intake and low physical activity. Studies showed that those factors were not only regulated by environment but also by genetic. However, the relationship is less been understood in obese children and adolescents. Objective: The objective of this study was to examine the role of SNPs in GHSR rs292216 and rs509035 on dietary intake in obese female adolescents. Methods: This is an observational study with cross sectional design. Respondents were obese female adolescents enrolled from obesity screening done in six junior high schools in Yogyakarta. Dietary intake was measured using 6 days 24 hours inconsecutive dietary recall. Genotyping of 2 SNPs from GHSR was done using FRLP-PCR. Results: There were 78 obese female adolescents joined this study. We found that no significant association between SNPs GHSR and dietary intake (p < 0.05). In addition, a SNP-SNP interaction analysis shown there is no difference between combination of GHSR rs292216 and rs509035 on dietary intake (p < 0.05). Conclusion: We concluded that SNPs on GHSR rs292216 and rs509035 were not related to dietary intake in Indonesian obese female adolescents. Further study is necessary to investigate the effect of those genes on dietary intake in the broader population.
机译：背景：肥胖与高饮食摄入和低运动量有关。研究表明，这些因素不仅受环境调节，而且受遗传因素调节。但是，肥胖儿童和青少年之间的关系了解得很少。目的：本研究的目的是研究GHSR rs292216和rs509035中SNP在肥胖女性青少年饮食中的作用。方法：这是一项具有横断面设计的观察性研究。受访者是在日惹的六所初中进行肥胖筛查的肥胖女性青少年。使用连续6天，不连续6天的饮食回想来测量饮食摄入量。使用FRLP-PCR对来自GHSR的2个SNP进行基因分型。结果：有78名肥胖女性青少年参加了这项研究。我们发现SNPs GHSR与饮食摄入量之间无显着相关性（p <0.05）。此外，SNP-SNP相互作用分析显示，GHSR rs292216和rs509035的组合在饮食摄入上没有差异（p <0.05）。结论：我们得出结论，印度尼西亚肥胖女性青少年GHSR rs292216和rs509035上的SNP与饮食摄入无关。有必要进行进一步的研究以研究这些基因对更广泛人群饮食摄入的影响。

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