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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Characterization of human herpes virus 8 genotypes in Kaposi's sarcoma patients in Tehran, Iran
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Characterization of human herpes virus 8 genotypes in Kaposi's sarcoma patients in Tehran, Iran

机译：伊朗德黑兰卡波济肉瘤患者中人类疱疹病毒8基因型的特征

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摘要

Kaposi's sarcoma (KS) associated with HHV8 is one of the common connective tissue malignancies especially in immunocompromised patients. The aim of the present study was to determine the common HHV8 genotypes in hospitalized patients in Tehran, Iran. A total of 36 archival paraffin-embedded KS tissue samples of patients with common characterization of KS were collected between 1999 to 2010 from hospitals in Tehran, Iran. After identifying the presence of HHV8 by amplification of its ORF 26 region, the ORF K1 region was amplified, sequenced and used for phylogenetic analysis. Among 30 ORF 26 positive cases, ORF K1 was amplified successfully in 14 cases. Consistent with other studies in Asia, subtype A (9 cases; 64.28%) and subtype C (5 cases; 35.71%) were detected by phylogenetic analysis. This result is in concordance with results from other countries of the region, however the ratio of genotype A to C is higher in our study compared to another study in the country.
机译：与HHV8相关的卡波西肉瘤（KS）是常见的结缔组织恶性肿瘤之一，尤其是在免疫功能低下的患者中。本研究的目的是确定伊朗德黑兰住院患者的常见HHV8基因型。在1999年至2010年之间，从伊朗德黑兰的医院共收集了36例具有KS共同特征的患者石蜡包埋的KS组织样本。通过扩增ORF 26区确定HHV8的存在后，将ORF K1区扩增，测序并用于系统发育分析。在30例ORF阳性病例中，有14例成功扩增了ORF K1。与亚洲其他研究一致，通过系统进化分析发现了A型（9例; 64.28％）和C型（5例; 35.71％）。该结果与该地区其他国家的结果一致，但是与该国的另一项研究相比，我们的研究中基因型A与C的比率更高。

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