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首页> 外文期刊>International journal of occupational medicine and environmental health. >Hemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene
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Hemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene

机译：单次或多次吸入半美仑酮后，大鼠肝，肺，肾和血液中的半美仑酮（1,2,3-三甲基苯）和肝，肺，肾和尿中的二甲基苯甲酸异构体

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Objectives: The aim of the study has been to explore hemimellitene distribution in blood, liver, lung and kidney as well as toxicokinetics of its elimination from blood of rats after single and repeated inhalation exposure to this compound. Tissue distribution and excretion with urine of 2-dimethylbenzoic acids (2,3-DMBA and 2,6-DMBA) were also evaluated. Material and Methods: Male outbred IMP:WIST rats were used in the experiment. The animals were exposed to hemimellitene vapors at the nominal concentration of 25 ppm, 100 ppm, and 250 ppm in the dynamic inhalation chambers for 6 h for single exposure purpose and for 4 weeks (6 h/day for 5 day/week) for repeated exposure purposes. Results: Significantly lower concentrations of hemimellitene were detected in the blood and tissues of animals after repeated inhalation exposure of animals to hemimellitene vapors, which points to reduced retention of the chemical in the lungs of the experimental rats. The trend of hemimellitene elimination from the blood depended solely on exposure intensity, irrespective of exposure time, both after single and repeated exposure. As regards the 2 determined hemimellitene metabolites, the major trend of the metabolic transformation involved formation of 2,3-DMBA. Conclusions: The significantly higher urinary 2,3-DMBA concentration after repeated exposure shows that hemimellitene induces enzymatic processes in the rat.
机译：目的：本研究的目的是探讨单次或多次吸入该化合物后半美白烯在血液，肝，肺和肾脏中的分布以及从大鼠血液中消除半美白烯的毒物动力学。还评估了2-二甲基苯甲酸（2,3-DMBA和2,6-DMBA）的组织分布和尿液排泄。材料和方法：实验中使用雄性近交的IMP：WIST大鼠。将动物在动态吸入室中分别暴露于标称浓度为25 ppm，100 ppm和250 ppm的半美林蒸气中，持续6小时以达到单次暴露目的，并持续4周（6小时/天，每天5天/周）重复曝光目的。结果：在反复将动物吸入半he草蒸气中后，在动物血液和组织中检测到的半mel草草浓度显着降低，这表明该化学物质在实验大鼠的肺中的保留减少。从血液中清除半美白效果的趋势完全取决于暴露强度，而与暴露时间无关，无论是一次暴露还是重复暴露。关于2种确定的半美白岩代谢物，代谢转化的主要趋势涉及2，3-DMBA的形成。结论：反复接触后尿中2,3-DMBA的浓度显着升高，表明半mellitene诱导了大鼠的酶促过程。

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