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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >LHRH and LHR genotypes and prostate cancer incidence and survival
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LHRH and LHR genotypes and prostate cancer incidence and survival

机译：LHRH和LHR基因型与前列腺癌的发生率和生存率

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Despite their crucial role in initiating steroid-hormone synthesis, the hypothalamic and pituitary hormones (LH, LHRH) and their receptors have received scant attention in genetic studies of hormone-related diseases. This study included 1,170 men diagnosed with prostate cancer (PC) in Los Angeles County between 1999 and 2003. LHRH and LH receptor genotypes were examined for association with PC survival. Additionally, associations with PC incidence were examined by comparing PC cases to control men of similar age and race/ethnicity. The LHR 312 G allele was found to be associated with increased PC mortality (p=0.01). Ten years after diagnosis, 16% of men carrying two copies of the G allele (genotype GG) had died of PC, compared to 11% of those with genotype AG and 9% of those with AA. In a case-control comparison, this same allele was significantly associated with decreased PC risk: OR=0.68 (95% CI: 0.49, 0.93) for genotype GG vs. AA. These results suggest that androgens may play opposing roles in PC initiation and progression, and highlight the need to include these important but overlooked genes in future studies of PC etiology, prognosis, and treatment.
机译：尽管下丘脑和垂体激素（LH，LHRH）及其受体在启动类固醇激素合成中起着至关重要的作用，但在激素相关疾病的遗传研究中却很少受到关注。这项研究包括1999年至2003年之间在洛杉矶县的1,170名被诊断患有前列腺癌（PC）的男性。检查了LHRH和LH受体基因型与PC生存的关系。此外，通过将PC病例与年龄和种族/民族相近的对照男性进行比较，检查了与PC发生率的相关性。发现LHR 312 G等位基因与PC死亡率增加相关（p = 0.01）。诊断十年后，携带两份G等位基因（基因型GG）的男性中有16％死于PC，而基因型AG的男性为11％，AA基因型的男性为9％。在病例对照比较中，相同的等位基因与PC风险降低显着相关：基因型GG与AA的OR = 0.68（95％CI：0.49，0.93）。这些结果表明，雄激素可能在PC的启动和发展中起相反的作用，并突出了在PC病因，预后和治疗的未来研究中包括这些重要但被忽视的基因的必要性。

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