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首页> 外文期刊>International Journal of Nephrology >Prognostic Importance of Fibroblast Growth Factor-23 in Dialysis Patients
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Prognostic Importance of Fibroblast Growth Factor-23 in Dialysis Patients

机译：成纤维细胞生长因子-23在透析患者中​​的预后重要性

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Introduction. In this study, we aimed to demonstrate the correlation of FGF-23 levels with bone-mineral metabolism, anemia, and the treatment in dialysis patients. Methods. Eighty-nine patients with similar age, gender, dialysis duration, and dialysis adequacy who were receiving hemodialysis replacement therapy for at least 6 months were included in the study. Serum iron, iron binding capacity, ferritin, hemoglobin (Hb), hematocrit (Htc), calcium (Ca), phosphorus (P), intact parathormone (iPTH), and FGF-23 levels were studied. In addition, active vitamin D and phosphate binders calcimimetic therapies that patients have received in the last 6 months were recorded. Results. It was determined that there was a positive correlation between serum FGF-23 values and PTH values () and CaP values (). A positive correlation was found between serum FGF-23 values and Ca values at a rate of 24,6% () and between values at a rate of 59,1% (). A positive correlation was determined between serum FGF-23 values and hemoglobin (Hb) values () and hematocrit (Htc) values (). In multivariate analysis, no significant correlation was found between serum FGF-23 levels and Hb and Htc. Conclusion. The effects of high serum FGF-23 levels on different parameters may be correlated with the development of refractory secondary hyperparathyroidism.
机译：介绍。在这项研究中，我们旨在证明FGF-23水平与骨代谢，贫血和透析患者治疗之间的相关性。方法。年龄，性别，透析时间和透析充分程度相近的89例接受血液透析替代治疗至少6个月的患者被纳入研究。研究了血清铁，铁结合能力，铁蛋白，血红蛋白（Hb），血细胞比容（Htc），钙（Ca），磷（P），完整副甲状腺激素（iPTH）和FGF-23水平。此外，记录了患者在最近6个月内接受的活性维生素D和磷酸盐结合剂拟钙剂疗法。结果。已确定血清FGF-23值与PTH值（）和CaP值（）之间呈正相关。发现血清FGF-23值与Ca值之间呈正相关，比率为24.6％（），而值之间呈正相关，比率为59,1％（）。血清FGF-23值与血红蛋白（Hb）值（）和血细胞比容（Htc）值（）之间呈正相关。在多变量分析中，血清FGF-23水平与Hb和Htc之间无显着相关性。结论。高血清FGF-23水平对不同参数的影响可能与难治性继发性甲状旁腺功能亢进的发展有关。

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