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首页> 外文期刊>International Journal of Nephrology >Acute Kidney Injury in Lymphoma: A Single Centre Experience
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Acute Kidney Injury in Lymphoma: A Single Centre Experience

机译：淋巴瘤的急性肾脏损伤：单中心经验。

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Background. Acute kidney injury (AKI) is a common but least studied complication of lymphoma.Objective. To determine the frequency and predictors of AKI in lymphoma and to study the impact of AKI on hospital stay and mortality.Methods. Retrospective review of medical records of hospitalized lymphoma patients aged ≥14 years between January 2008 and December 2011 was done.Results. Out of 365 patients, AKI was present in 31.8% (116/365). Multivariate logistic regression analysis showed that independent predictors for AKI included sepsis (odds ratio (OR) 3.76; 95% CI 1.83–7.72), aminoglycosides (OR 4.75; 95% CI 1.15–19.52), diuretics (OR 2.96; 95% CI 1.31–6.69), tumor lysis syndrome (OR 3.85; 95% CI 1.54–9.59), and R-CVP regimen (OR 4.70; 95% CI 1.20–18.36). AKI stages 2 and 3 was associated with increased hospital stay (OR 2.01; 95% CI 1.19–3.40).Conclusion. AKI was significantly associated with sepsis, aminoglycoside, diuretics, presence of tumor lysis syndrome, and use of R-CVP regimen. Presence of AKIN (Acute Kidney Injury Network) stages 2 and 3 AKI had increased hospital stay. AKI was also associated with increased mortality.
机译：背景。急性肾损伤（AKI）是淋巴瘤的常见但研究最少的并发症。目的确定淋巴瘤中AKI的发生频率和预测指标，并研究AKI对住院时间和死亡率的影响。回顾性分析了2008年1月至2011年12月间≥14岁的住院淋巴瘤患者的病历。在365名患者中，AKI占31.8％（116/365）。多元逻辑回归分析显示，AKI的独立预测因素包括败血症（赔率（OR）3.76; 95％CI 1.83–7.72），氨基糖苷类药物（OR 4.75; 95％CI 1.15-19.52），利尿剂（OR 2.96; 95％CI 1.31） –6.69），肿瘤溶解综合征（OR 3.85; 95％CI 1.54–9.59）和R-CVP方案（OR 4.70; 95％CI 1.20-18.36）。 AKI第2和第3阶段与住院时间增加相关（OR 2.01; 95％CI 1.19–3.40）。 AKI与败血症，氨基糖苷，利尿剂，肿瘤溶解综合征的存在以及R-CVP方案的使用显着相关。 AKIN（急性肾脏损伤网络）第2阶段和第3阶段的存在增加了住院时间。 AKI也与死亡率增加有关。

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