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首页> 外文期刊>International Journal of Nephrology >Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease
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Cystatin C as a Predictor of Mortality and Cardiovascular Events in a Population with Chronic Kidney Disease

机译：胱抑素C作为慢性肾脏病人群死亡率和心血管事件的预测因子

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Background. We examine whether cystatin C, a surrogate marker of renal function, could identify patients with chronic kidney disease (CKD) with an increased risk of renal disease progression, death, or cardiovascular events.Methods. Data were obtained for 180 patients, with a diagnosis of chronic renal failure based on serum creatinine estimated glomerular filtration rate (eGFRcreat) <90 mL/min/1.73 m2. This population was grouped in tertiles according to cystatin C and creatinine values at baseline. Cardiovascular events and overall mortality were estimated for each tertile. Predictors of overall mortality and for the development of renal disease progression were analyzed.Results. The median age was 75 years (interquartile range 69–82) and the median eGFRcreat38 mL/min m2(interquartile range 33–49). Overall mortality was lower on the first and on the second tertiles of cystatin C than on the third one (HR = 0.060; 95% CI: 0.008–0.447 and HR = 0.094; 95% CI: 0.022–0.406, resp.). Deaths related to the creatinine tertiles followed the same pattern, but differences were not as large. Cardiovascular mortality was lower on the second than on the third cystatin C tertile (HR = 0.198; 95% CI: 0.040–0.987), but it did not show differences on the first and the second creatinine tertiles compared with the third one (HR = 0.126; 95% CI: 0.013–1.265 and HR = 0.403; 95% CI: 0.093–1.740). The only independent predictors of mortality during followup were baseline cystatin C (OR = 0.100; 95% CI: 0.021–0.463) and baseline uric acid (OR = 1.377; 95% CI: 1.070–1.773).Conclusion. Cystatin C may be an alternative to creatinine for detecting a high risk of death and cardiovascular events in a population with CKD.
机译：背景。我们检查了半胱氨酸蛋白酶抑制剂C（一种肾脏功能的替代标志物）是否可以识别出患有慢性肾脏病（CKD）的患者，而这些患者的肾脏疾病进展，死亡或心血管事件的风险增加。获得了180例患者的数据，根据血清肌酐估计的肾小球滤过率（eGFRcreat）<90

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