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首页> 外文期刊>International Journal of Nephrology >Morphological Characterization of the Polyflux 210H Hemodialysis Filter Pores
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Morphological Characterization of the Polyflux 210H Hemodialysis Filter Pores

机译：Polyflux 210H血液透析滤孔的形态表征

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Background. Morphological characterization of hemodialysis membranes is necessary to improve pore design.Aim. To delineate membrane pore structure of a high flux filter, Polyflux 210H.Methods. We used a Joel JSM-6010LV scanning electron microscope (SEM) and a SU6600 Hitachi field emission scanning electron microscope (FESEM) to characterize the pore and fiber morphology. The maximal diameters of selected uremic toxins were calculated using the macromolecular modeling Crystallographic Object-Oriented Toolkit (COOT) software.Results. The mean pore densities on the outermost and innermost surfaces of the membrane were 36.81% and 5.45%, respectively. The membrane exhibited a tortuous structure with poor connection between the inner and outer pores. The aperture’s width in the inner surface ranged between 34 and 45 nm, which is 8.76–11.60 times larger than the estimated maximum diameter ofβ2-microglobulin (3.88 nm).Conclusion. The results suggest that the diameter size of inner pore apertures is not a limiting factor to middle molecules clearance, the extremely diminished density is. Increasing inner pore density and improving channel structure are strategies to improve clearance of middle molecules.
机译：背景。血液透析膜的形态表征对于改善孔设计是必要的。为了描述高通量过滤器的膜孔结构，Polyflux 210H。我们使用Joel JSM-6010LV扫描电子显微镜（SEM）和SU6600日立场发射扫描电子显微镜（FESEM）来表征孔和纤维的形态。使用大分子建模晶体对象导向工具包（COOT）软件计算所选尿毒症毒素的最大直径。膜的最外表面和最内表面的平均孔密度分别为36.81％和5.45％。该膜表现出曲折的结构，在内孔和外孔之间的连接不良。该孔的内表面宽度在34至45 nm之间，是估计的β2-微球蛋白最大直径（3.88 nm）的8.76–11.60倍。结果表明，内孔孔径的大小不是限制中间分子清除的限制因素，而密度却大大降低。增加内部孔密度和改善通道结构是提高中间分子清除率的策略。

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