• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Nephrology >Fibroblast Growth Factor and Mineral Metabolism Parameters among Prevalent Kidney Transplant Patients
【24h】

Fibroblast Growth Factor and Mineral Metabolism Parameters among Prevalent Kidney Transplant Patients

机译：肾脏移植患者中成纤维细胞生长因子和矿物质代谢参数

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. Chronic kidney disease (CKD) related mineral bone disorders persist after kidney transplantation, but little is known about the relationship between fibroblast growth factor-23 (FGF-23) and mineral metabolism in prevalent post-transplant patients. Objectives. To examine mineral metabolism parameters and their relationship to FGF-23 and parathyroid hormone (PTH) in prevalent kidney transplant patients. Methods. Cross-sectional study of 106 kidney transplant patients enrolled November 2005–October 2009 at Tufts Medical Center (TMC), Boston. Results. The prevalence of hypophosphatemia was 34%, hypercalcemia 3%, and elevated PTH levels 66%, at a median (25th–75th percentile) duration of 12.8 (7.5–30.9) months post-transplant. Males had significantly higher levels of PTH (P=0.04) and lower levels of serum phosphate(P=0.002). Serum PTH levels did not relate to eGFR, corrected calcium levels or serum phosphate. FGF-23 levels were above the reference limits in 7% of patients; higher levels were associated with higher serum phosphate and PTH levels after adjustment for transplant kidney function. Conclusion. FGF-23 is an important driver of mineral metabolism in prevalent transplant patients. Its modulatory role in mineral metabolism homeostasis may be heightened as feedback suppression of PTH is disturbed. Its role in long term cardiovascular and graft outcomes needs further study.
机译：背景。肾脏移植后，慢性肾脏病（CKD）相关的矿物质骨疾病仍然存在，但对于普遍的移植后患者，成纤维细胞生长因子-23（FGF-23）与矿物质代谢之间的关系知之甚少。目标。目的检查肾脏移植患者中矿物质代谢参数及其与FGF-23和甲状旁腺激素（PTH）的关系。方法。 2005年11月至2009年10月在波士顿塔夫茨医学中心（TMC）进行的106位肾脏移植患者的横断面研究。结果。移植后低磷血症的患病率为34％，高钙血症为3％，PTH水平升高为66％，中位（25％至75％）持续时间为12.8（7.5-30.9）个月。男性的PTH水平显着较高（P = 0.04），血清磷酸盐水平较低（P = 0.002）。血清PTH水平与eGFR，校正的钙水平或血清磷酸盐无关。 7％的患者中FGF-23水平高于参考限值;调整移植肾功能后，较高的水平与较高的血清磷酸盐和PTH水平相关。结论。 FGF-23是普遍移植患者中矿物质代谢的重要驱动器。由于PTH的反馈抑制受到干扰，其在矿物质代谢稳态中的调节作用可能会增强。它在长期心血管和移植结果中的作用有待进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号