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首页> 外文期刊>International Journal of Nephrology >Pre-, Pro-, and Synbiotics: Do They Have a Role in Reducing Uremic Toxins? A Systematic Review and Meta-Analysis
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Pre-, Pro-, and Synbiotics: Do They Have a Role in Reducing Uremic Toxins? A Systematic Review and Meta-Analysis

机译：前，前和合生元：它们在减少尿毒症毒素中是否起作用？系统评价和荟萃分析

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Objective. This paper assessed the effectiveness of pre-, pro-, and synbiotics on reducing two protein-bound uremic toxins, p-cresyl sulphate (PCS) and indoxyl sulphate (IS). Methods. English language studies reporting serum, urinary, or fecal PCS and/or IS (or their precursors) following pre-, pro-, or synbiotic interventions (>1 day) in human adults were included. Population estimates of differences in the outcomes between the pre- and the postintervention were estimated for subgroups of studies using four meta-analyses. Quality was determined using the GRADE approach. Results. 19 studies met the inclusion criteria, 14 in healthy adults and five in haemodialysis patients. Eight studies investigated prebiotics, six probiotics, one synbiotics, one both pre- and probiotics, and three studies trialled all three interventions. The quality of the studies ranged from moderate to very low. 12 studies were included in the meta-analyses with all four meta-analyses reporting statistically significant reductions in IS and PCS with pre- and probiotic therapy. Conclusion. There is a limited but supportive evidence for the effectiveness of pre- and probiotics on reducing PCS and IS in the chronic kidney disease population. Further studies are needed to provide more definitive findings before routine clinical use can be recommended.
机译：目的。本文评估了前合生元，前合生元和合生元在减少两种蛋白质结合的尿毒症毒素（对甲苯基硫酸盐（PCS）和吲哚酚硫酸盐（IS））方面的有效性。方法。包括英语报告，该报告报告了在成年人中进行前，益生或合生元干预（> 1天）后的血清，尿或粪便PCS和/或IS（或其前体）。使用四个荟萃分析对研究亚组的干预前和干预后结局差异进行总体估计。使用GRADE方法确定质量。结果。 19项研究符合纳入标准，健康成人14例，血液透析患者5例。八项研究调查了益生元，六种益生菌，一种合生元，一种益生元和益生菌，三项研究对所有三种干预进行了试验。研究的质量从中等到非常低不等。荟萃分析中包括12项研究，所有四项荟萃分析均报告了使用益生菌和益生菌治疗后IS和PCS的统计学降低。结论。对于慢性肾脏病人群中，益生菌和益生菌对降低PCS和IS的有效性有有限但支持的证据。在建议常规临床使用之前，需要进一步研究以提供更多明确的发现。

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