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首页> 外文期刊>International Journal of Molecular Medicine and Advance Sciences >Paracrine Transformation to Autocrine Autonomy in Tumor Cell Proliferation and Spread. Is the Neoplastic Blood Supply a Functional Determinant of Clonality In Inducing Biologic Tumor Progressiveness?
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Paracrine Transformation to Autocrine Autonomy in Tumor Cell Proliferation and Spread. Is the Neoplastic Blood Supply a Functional Determinant of Clonality In Inducing Biologic Tumor Progressiveness?

机译：旁分泌转化为肿瘤细胞增殖和扩散中的自分泌自主性。肿瘤血液供应是否是诱导生物学肿瘤进展的克隆性的功能决定因素？

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A theory of selectivity in terms of clonal progression of neoplasms might directly implicate a primary susceptibility of blood supply systems in transformation of paracrine responsiveness to autocrine autonomy. Subsequent neoplastic evolution might constitute forms of establishment of aberrant vascularity in inducing a clonality of tumor cell subpopulations that are integrally a single system of progression through transformation. In various ways, the active processes of tumor cell proliferation and spread through infiltration and metastases would paradoxically constitute systems of operative autonomy within a context of evolving influence. Indeed, clonality of neoplastic progression might involve a transformation that integrally evolves simply as patterns of aberrant blood supply both in initial establishment and in subsequent evolution towards higher tumor grades. In simple terms, perhaps, one might speak of different modes of evolving transformation of tumor cells as clonally derived cells centered on aberrant blood supply that is inherently a point of reference in terms even of basic malignant transformation as a carcinogenic event. Beyond even considerations of strict initial malignant transformation, however, aberrant blood supply systems would constitute a persistent source of transformation in establishing neoplastic progression in terms largely of biologic attributes of clonality towards transformation of paracrine responsiveness to autocrine autonomy.
机译：关于肿瘤的克隆进展的选择性理论可能直接暗示了血液供应系统对旁分泌对自分泌自主性的反应的主要敏感性。随后的赘生物进化可能构成异常血管形成的形式，从而诱导肿瘤细胞亚群的克隆性，这些肿瘤亚群整体上是通过转化而发展的单一系统。在各种影响下，肿瘤细胞通过浸润和转移扩散和扩散的活跃过程将自相矛盾地构成手术自主系统。确实，肿瘤进展的克隆性可能涉及一种转变，该转变简单地以最初建立时和随后向更高肿瘤等级的演变中异常血液供应的方式发展。用简单的术语来说，也许可以说是肿瘤细胞进化转化的不同模式，因为克隆衍生的细胞以异常的血液供应为中心，就基本的恶性转化为致癌事件而言，这是固有的参照点。然而，除了考虑严格的初始恶性转化外，异常的血液供应系统将在建立肿瘤进展方面构成转化的持久来源，这在很大程度上取决于克隆性对旁分泌对自分泌自主性的转化的生物学特性。

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