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首页> 外文期刊>International journal of oral science >The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein
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The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein

机译：牙本质唾液蛋白-磷酸化蛋白和牙本质唾液蛋白的功能意义

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Phosphophoryn (PP) and dentin sialoprotein (DSP) are the most dominant non-collagenous proteins in dentin. PP is an extremely acidic protein that can function as a mineral nucleator for dentin mineralization. DSP was first identified in 1981, yet its functional significance is still controversial. Historically, these two proteins were considered to be independently synthesized and secreted by dental pulp cells into the developing dentin matrix. However, with the identification of the DSP coding sequence in 1994, followed 2 years later by the finding that the PP coding sequence was located immediately downstream from the DSP sequence, it became immediately clear that DSP and PP proteins were derived from a single DSP-PP (i.e., dentin sialophosphoprotein, DSPP) transcript. Since DSPP cDNA became available, tremendous progress has been made in studying DSP-PP mRNA distribution and DSP generation from the DSP-PP precursor protein at specific cleavage sites by protease tolloid-related-1 (TLR1) or bone morphogenetic protein 1 (BMP1). The functions of DSP-PP and DSP were investigated via DSP-PP knockout (KO) and DSP knockin in DSP-PP KO mice. In addition, a number of in vitro studies aimed to elucidate DSPP and DSP function in dental pulp cells.
机译：磷光蛋白（PP）和牙本质唾液蛋白（DSP）是牙本质中最主要的非胶原蛋白。 PP是一种极酸性的蛋白质，可以充当牙本质矿化的矿物成核剂。 DSP于1981年首次被确定，但其功能意义仍存在争议。历史上，这两种蛋白被认为是独立合成的，并由牙髓细胞分泌到发育中的牙本质基质中。但是，在1994年确定了DSP编码序列后，两年后又发现PP编码序列位于DSP序列的直接下游，因此，很明显，DSP和PP蛋白源自单个DSP- PP（即牙本质唾液磷蛋白，DSPP）转录本。自从DSPP cDNA可用以来，在研究蛋白酶Tolloid-related-1（TLR1）或骨形态发生蛋白1（BMP1）在特定切割位点处从DSP-PP前体蛋白产生DSP-PP mRNA分布和DSP产生方面取得了巨大进展。 。通过DSP-PP敲除（KO）和DSP敲入在DSP-PP KO小鼠中研究了DSP-PP和DSP的功能。此外，许多体外研究旨在阐明牙髓细胞中的DSPP和DSP功能。

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