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首页> 外文期刊>International Journal of Neonatal Screening >The Risk from Anti-Thyroid Hormone Antibody Interference in Neonatal Congenital Hypothyroidism Screening
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The Risk from Anti-Thyroid Hormone Antibody Interference in Neonatal Congenital Hypothyroidism Screening

机译：新生儿先天性甲状腺功能减退症筛查中抗甲状腺激素抗体干扰的风险

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Neonatal congenital hypothyroidism screening is considered to be one of the most effective newborn screening strategies. Neonatal screening for congenital hypothyroidism involves the analysis of thyroid hormone and thyrotropin levels using an immunoassay based technique. Immunoassays are also prone to analytical problems such as assay interference. Immunoassays used for thyroid hormone measurement are known to be affected from anti-thyroid hormone antibody interference. This is the first reported case of interference presumably caused by anti-thyroid hormone antibodies transferred from mother to child during pregnancy, affecting the measurement of free-thyroxine in a cord-blood sample. We report a case of a full-term newborn with presumed anti-thyroid hormone antibody interference present in both cord blood and subsequent venous blood samples. In the context of a newborn screening programme based solely on thyroxine measurement, this is an important finding, since it has the potential to cause false negative screening results.
机译：新生儿先天性甲状腺功能减退症筛查被认为是最有效的新生儿筛查策略之一。新生儿筛查先天性甲状腺功能减退症涉及使用基于免疫测定的技术分析甲状腺激素和促甲状腺激素水平。免疫测定也容易产生分析问题，例如测定干扰。已知用于甲状腺激素测量的免疫测定会受到抗甲状腺激素抗体干扰的影响。这是首次报道的干扰病例，可能是由于怀孕期间从母亲转移到孩子的抗甲状腺激素抗体引起的，从而影响了脐带血样品中游离甲状腺素的测定。我们报道一例足月新生儿，其脐血和随后的静脉血样本中均存在推测的抗甲状腺激素抗体干扰。在仅基于甲状腺素测量的新生儿筛查程序中，这是一个重要发现，因为它可能导致假阴性筛查结果。

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