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首页> 外文期刊>International Journal of Pediatrics >Normal Thymic Size and Low Rate of Infections in Human Donor Milk Fed HIV-Exposed Uninfected Infants from Birth to 18 Months of Age
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Normal Thymic Size and Low Rate of Infections in Human Donor Milk Fed HIV-Exposed Uninfected Infants from Birth to 18 Months of Age

机译：出生至18个月大的人供乳喂养的HIV感染的未感染婴儿的正常胸腺大小和较低的感染率

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Objective. To evaluate the immune function in HIV-exposed uninfected (HIV-EU) infants fed human donor milk.Methods. Ultrasound-obtained thymic index (Ti), T-lymphocyte subsets, and the number of infections were examined from birth to 18 months of age in 18 HIV-EU infants. The infants were compared to a cohort of 47 term, HIV-unexposed breastfed or formula-fed infants.Results. The thymic size at 12 months of age was not significantly different between the HIV-EU group and the control infants (P=0.56). At 4 months of age, the HIV-EU infants had significantly fewer infections than the control infants (P<0.001). Furthermore, in the control group, the infants exclusively breastfed at 4 months of age had significantly fewer infections at 8 months when compared to age-matched formula-fed infants (P=0.001).Conclusion. HIV-EU infants fed human donor milk have normal growth of thymus and contract fewer infections than other healthy infants. This finding along with fewer infections in exclusively breastfed infants compared to formula-fed infants supports the beneficial effect of human milk on the immune system. We suggest, when breastfeeding is not possible, that providing human donor milk to vulnerable groups of infants will be beneficial for their maturing immune system.
机译：目的。为了评估喂食人供体乳的未接触HIV的未感染（HIV-EU）婴儿的免疫功能。检查了18例HIV-EU婴儿从出生到18个月的超声获取的胸腺指数（Ti），T淋巴细胞亚群和感染数。将这些婴儿与47名足月，未暴露HIV的母乳喂养或配方喂养的婴儿进行比较。 HIV-EU组和对照组婴儿在12个月大时胸腺大小无显着差异（P = 0.56）。在4个月大时，HIV-EU婴儿的感染明显少于对照组婴儿（P <0.001）。此外，在对照组中，与年龄相匹配的配方奶喂养的婴儿相比，仅4个月大的母乳喂养的婴儿在8个月时的感染显着减少（P = 0.001）。用人类供体乳喂养的HIV-EU婴儿的胸腺正常生长，感染率比其他健康婴儿少。与配方奶喂养的婴儿相比，这一发现以及纯母乳喂养的婴儿感染较少，支持了母乳对免疫系统的有益作用。我们建议，在无法进行母乳喂养的情况下，向脆弱的婴儿群体提供人类捐赠的牛奶将有利于他们成熟的免疫系统。

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