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首页> 外文期刊>International Journal of Pediatrics >Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy?
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Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy?

机译：扩张性心肌病患者的血清Tenascin-C可以用作炎症的标志吗？

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Background. Tenascin-C (TN-C) is an extracellular matrix glycoprotein that appears at sites of inflammation in cardiac pathologies.Aim of the Work. To evaluate the role of TN-C as a marker for active inflammation in children with dilated cardiomyopathy (DCM).Subjects and Methods. 24 consecutive patients with primary nonfamilial DCM aged 6–72 months (mean45.19±11.03) were divided into group I, twelve patients with acute onset DCM (<6 months duration), and group II, twelve patients with chronic DCM (>6 months duration), and compared to 20 healthy age- and sex-matched controls. Investigations included estimation of serum TN-C and echocardiographic evaluation using M-mode and 2D speckle tracking echocardiography (STE).Results. Serum TN-C showed a higher significant statistical elevation among patients than controls (P<0.001) and in group I than group II (P<0.001). EF was significantly decreased, and LVEDD and EDV increased in patients than controls and in GI than GII. STE showed a statistically significant difference in global peak strain longitudinal (GPSL) average in patients than controls (P<0.05) and between GI and GII (P<0.001). STE wall motion scoring showed normokinesia (33.5%), hypokinesia (8.33%), and akinesia (50%) in GI and hypokinesia (100%) in GII. There was a statistically significant positive correlation between serum TN-C and GPSL average.Conclusions. Increased serum TN-C can be used as a marker of inflammation in DCM and is associated with the severity of heart failure and LV dysfunction as detected by STE.
机译：背景。 Tenascin-C（TN-C）是一种细胞外基质糖蛋白，出现在心脏病理学中的炎症部位。评估TN-C作为扩张型心肌病（DCM）儿童活动性炎症标记物的作用。对象和方法。连续24例年龄在6-72个月之间的原发性非家族性DCM患者（平均45.19±11.03）分为I组，十二例急性DCM患者（持续时间<6个月），II组十二例慢性DCM患者（> 6）个月的持续时间），并与20位年龄和性别相匹配的健康对照进行比较。研究包括血清TN-C估计以及使用M型和2D斑点跟踪超声心动图（STE）的超声心动图评估。血清TN-C在患者中的统计学显着性高于对照组（P <0.001），而在I组中则高于II组（P <0.001）。患者的EF显着降低，而LVEDD和EDV高于对照组，而GI高于GII。 STE在患者中的全球总体峰值应变纵向（GPSL）平均水平与对照组相比差异有统计学意义（P <0.05），在GI和GII之间差异显着（P <0.001）。 STE壁运动评分在GI中显示正常运动（33.5％），运动不足（8.33％）和运动缺乏（50％），在GII中显示运动不足（100％）。血清TN-C与GPSL平均值之间存在统计学意义的正相关。血清TN-C升高可作为DCM中炎症的标志物，并与STE检测到的心力衰竭和LV功能障碍的严重程度有关。

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