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首页> 外文期刊>International Journal of Pediatrics >Doxapram Use for Apnoea of Prematurity in Neonatal Intensive Care
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Doxapram Use for Apnoea of Prematurity in Neonatal Intensive Care

机译：Doxapram用于新生儿重症监护室早产呼吸暂停

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Apnoea of prematurity is treated with noninvasive respiratory therapy and methylxanthines. For therapy unresponsive apnoea doxapram is often prescibed in preterm neonates. The duration, dosage and route of administration of doxapram together with its efficacy was evaluated in two Dutch neonatal intensive care. Outcome concerning short-term safety and neonatal morbidity were evaluated. During 5 years, 122 of 1,501 admitted newborns <32 weeks of gestational age received doxapram. 64.8% of patients did not need intubation after doxapram. 25% of treated neonates were <27 weeks of gestation. A positive response to doxapram therapy on apnoea was associated with longer duration of doxapram usage (P<0.001), lower mean doses (P<0.003), and less days of intensive care (median 33 versus 42 days;P<0.002). No patients died during doxapram therapy. Incidence of necrotizing enterocolitis, intraventricular hemorrhage, periventricular leukomalacia, retinopathy of prematurity, persistent ductus arteriosus, or worsening of pulmonary condition did not increase during doxapram therapy. Doxapram is frequently used for apnoea of prematurity, despite a lack of data on short-term efficacy and long-term safety. Until efficacy and safety are confirmed in prospective trials, doxapram should be used with caution.
机译：用无创呼吸疗法和甲基黄嘌呤治疗早产儿呼吸暂停。对于治疗，无反应的呼吸暂停多沙普仑经常在早产儿中发作。在两个荷兰新生儿重症监护室中评估了多沙普兰的持续时间，剂量和给药途径及其疗效。评价有关短期安全性和新生儿发病率的结果。在5年中，小于32个胎龄的1,501名入院新生儿中有122名接受了多沙普仑治疗。多沙普兰术后不需要插管的患者占64.8％。接受治疗的新生儿中有25％的妊娠小于27周。对多沙普仑治疗呼吸暂停的阳性反应与使用多沙普仑的持续时间较长（P <0.001），平均剂量较低（P <0.003）和重症监护天数较少（中位数33天比42天; P <0.002）有关。在多沙普仑治疗期间无患者死亡。在多沙普仑治疗期间，坏死性小肠结肠炎，脑室内出血，脑室白细胞软化，早产儿视网膜病变，持续性导管动脉硬化或肺部疾病恶化的发生率并未增加。尽管缺乏短期疗效和长期安全性方面的数据，但多沙普仑经常用于早产呼吸暂停。在前瞻性试验中确认疗效和安全性之前，应谨慎使用多沙普仑。

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