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首页> 外文期刊>International Journal of Oral & Maxillofacial Pathology >Altered Trace Element Level and Antioxidant Activity in whole blood of Oral Leukoplakia and Cancer patients in comparison with healthy controls
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Altered Trace Element Level and Antioxidant Activity in whole blood of Oral Leukoplakia and Cancer patients in comparison with healthy controls

机译：与健康对照组相比，口腔白斑和癌症患者全血中微量元素水平和抗氧化活性的变化

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14.00 800x600 Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} Background: Leukoplakia, the most common oral precancerous lesion is a deleterious consequence of prolonged tobacco intake either in smoke or smokeless form. Apart from the well-known risk factors involved in malignant transformation of such potentially malignant disorder, imbalance in trace element profile and associated oxidative stress has recognizable impact in the process of carcinogenesis. Aim: To evaluate the level of the trace elements (Zinc, Copper, Manganese and selenium) and Superoxide dismutase (antioxidant) enzyme activity in whole blood of leukoplakia and oral cancer patients. Materials and Methods: A case control study comprises of 3 study groups of healthy controls (n=30), oral leukoplakia (n=60) and oral cancer (n=60) patients. Trace element concentration and Superoxide Dismutase enzyme activity in whole blood was measured by Energy Dispersive X-Ray Fluorescence and Photo-spectrometry respectively. The results were analysed by using One Way-ANOVA and Student’s- t statistical tests. Result: The data analysis revealed remarkable alteration in the trace elemental concentration as Zinc and Selenium concentration was lowered in both precancer and cancer patients as compared to that of the controls. Whereas concentration of Copper was progressively and significantly increased from precancer to cancer group. Manganese showed an inverse pattern in both disease groups. Superoxide Dismutase enzyme activity was significantly (p≤0.05) lowered in both leukoplakia and cancer patients. Conclusion: The present study highlighted about relationship between alternation in the level of trace elements, oxidative stress and leukoplakia. Concerted efforts would, therefore, help in early detection, management and monitoring the efficacy of available treatment.
机译：14.00 800x600正常0否否否EN-US X-NONE X-NONE MicrosoftInternetExplorer4 / *样式定义* / table.MsoNormalTable {mso-style-name：“ Table Normal”; mso-tstyle-rowband-size：0; mso-tstyle-colband-size：0; mso-style-noshow：是; mso-style-priority：99; mso-style-parent：“”; mso-padding-alt：0in 5.4pt 0in 5.4pt; mso-para-margin：0in; mso-para-margin-bottom：.0001pt; mso分页：寡妇孤儿;字体大小：10.0pt;字体族：“ Times New Roman”，“ serif”;}背景：白斑，最常见的口腔癌前病变是长期吸烟或无烟烟草的有害后果。除了与这种潜在恶性疾病的恶性转化有关的众所周知的危险因素外，微量元素分布不平衡和相关的氧化应激在致癌过程中也具有公认的影响。目的：评估白斑和口腔癌患者全血中的微量元素（锌，铜，锰和硒）和超氧化物歧化酶（抗氧化剂）的活性。材料和方法：一项病例对照研究包括3个健康对照组（n = 30），口腔白斑（n = 60）和口腔癌（n = 60）患者的研究组。全血中的微量元素浓度和超氧化物歧化酶活性分别通过能量色散X射线荧光法和光光谱法测定。结果采用单向方差分析和Student-t统计检验进行了分析。结果：数据分析表明，与对照组相比，癌症前期患者和癌症患者中痕量元素的浓度均发生显着变化，因为锌和硒的浓度均降低。而从癌前组到癌症组，铜的浓度逐渐增加。锰在两个疾病组中均显示出相反的模式。在白斑和癌症患者中，超氧化物歧化酶活性均显着降低（p≤0.05）。结论：本研究强调了微量元素水平变化，氧化应激与白斑之间的关系。因此，齐心协力将有助于及早发现，管理和监测现有治疗的有效性。

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