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首页> 外文期刊>International Journal of Phytopharmacy >Microencapsulated Garcinia kola and Hunteria umbellata Seeds Aqueous Extracts - Part 2: Influence of Some Selected Pharmaceutical Excipients
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Microencapsulated Garcinia kola and Hunteria umbellata Seeds Aqueous Extracts - Part 2: Influence of Some Selected Pharmaceutical Excipients

机译：微囊藤黄和Hunteria umbellata种子水提取物-第2部分：某些药物赋形剂的影响

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Objective: This study investigates the effect of selected excipients on microcapsules properties of seeds extracts of Garcinia kola (GK) and Hunteria umbellata (HU). Method: Extracts from macerated dried powdered seeds were microencapsulated with chitosan-alginate including either talc, HPMCAS, Eudragit ? RLPO or Eudragit ? L100 up to 25% in the core. Microcapsules were characterized using differential scanning calorimertry (DSC), X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and In vitro release. Results: DSC, XRD and FTIR showed no change in crystalline properties and functional groups of microcapsules and excipients in the formulations. In vitro extract release showed retardation of extract release in acid medium after 2 h and between 80 to 100% at pH 6.8. Generally, the microcapsules fitted more closely to first order model than the other models. Conclusion: Inclusion of these excipients did not impart negatively in interaction and release profile on microcapsules containing GK and HU aqueous extracts and can therefore be added to facilitate microcapsule production and enhance dosage form performance.
机译：目的：本研究旨在研究赋形剂对藤黄（Garcinia kola，GK）和伞形果（Hunteria umbellata，HU）种子提取物微囊特性的影响。方法：将浸软的干粉状种子的提取物用壳聚糖-海藻酸酯（包括滑石粉，HPMCAS，Eudragit？）微囊化。 RLPO还是Eudragit？ L100核心可达25％。使用差示扫描量热法（DSC），X射线衍射法（XRD），傅里叶变换红外光谱（FTIR）和体外释放对微胶囊进行表征。结果：DSC，XRD和FTIR在制剂中的微胶囊和赋形剂的结晶特性和官能团均未发生变化。体外提取物释放显示出在2 h后在pH 6.8下80％至100％之间的酸性介质中提取物释放的延迟。通常，与其他模型相比，微胶囊更适合一级模型。结论：这些赋形剂的加入不会对含有GK和HU水提取物的微胶囊的相互作用和释放特性产生负面影响，因此可以添加这些赋形剂以促进微胶囊的生产并增强剂型性能。

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