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首页> 外文期刊>International Journal of Physiology, Pathophysiology and Pharmacology >Ascorbic acid and sodium benzoate synergistically aggravates testicular dysfunction in adult Wistar rats
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Ascorbic acid and sodium benzoate synergistically aggravates testicular dysfunction in adult Wistar rats

机译：抗坏血酸和苯甲酸钠协同加重成年Wistar大鼠睾丸功能障碍

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Background: The effect of the concomitant use of sodium benzoate (NaB) and ascorbic acid on human health remains controversial. Therefore, the current study is designed to investigate the effect of NaB and ascorbic acid on the testicular function of adult Wistar rats. Methods: Adult Wistar rats were randomly allotted into Control (vehicle; received 1 ml of distilled water), NaB-treated (SB-treated; received 100 mg/kg body weight; b.w), ascorbic acid-treated (AA-treated; received 150 mg/kg b.w) and NaB+ ascorbic acid-treated (SB+AA-treated) groups. The treatment lasted for 28 days and the administration was given orally. The body weight change was monitored. Semen analysis, biochemical assay and histological examination were performed. Results: Treatment with NaB significantly altered the cytoarchitecture of testicular tissue, sperm quality, testicular endocrine function and oxidative stress status without any alteration in body weight gain compared to control. In addition, treatment with NaB+ ascorbic acid exacerbated testicular tissue disruption, impaired sperm quality and testicular endocrine impairment with significant reduction in oxidative stress and unaltered body weight gain when compared with NaB-treated group. Conclusion: This study suggests that ascorbic acid and NaB synergistically aggravates testicular dysfunction. This is independent of oxidative stress status.
机译：背景：苯甲酸钠（NaB）和抗坏血酸同时使用对人体健康的影响仍存在争议。因此，本研究旨在研究NaB和抗坏血酸对成年Wistar大鼠睾丸功能的影响。方法：将成年Wistar大鼠随机分配至对照组（车辆;接受1 ml蒸馏水），NaB处理（SB处理;体重100 mg / kg体重;体重），抗坏血酸处理（AA处理;接受体重）。 150 mg / kg体重）和NaB +抗坏血酸处理（SB + AA处理）组。治疗持续28天，并且口服给予。监测体重变化。进行精液分析，生化分析和组织学检查。结果：与对照组相比，NaB处理可显着改变睾丸组织的细胞结构，精子质量，睾丸内分泌功能和氧化应激状态，而体重增加没有任何改变。此外，与NaB治疗组相比，NaB +抗坏血酸治疗加重了睾丸组织破坏，精子质量受损和睾丸内分泌损伤，氧化应激显着降低，体重增加未改变。结论：这项研究表明抗坏血酸和NaB协同加重了睾丸功能障碍。这与氧化应激状态无关。

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