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首页> 外文期刊>International Journal of Pharmaceutical Sciences and Research >SCREENING FOR BIOLOGICAL ACTIVITIES OF THE TRADITIONAL CHINESE MEDICINE FANG FENG TONG SHEN SAN
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SCREENING FOR BIOLOGICAL ACTIVITIES OF THE TRADITIONAL CHINESE MEDICINE FANG FENG TONG SHEN SAN

机译：中药复方参神散生物活性的筛选。

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The ancient Chinese formulation Fang Feng Tong Shen San (FFTSS) consists of 17 components. The purpose of this study was to investigate the anti-inflammatory, antioxidant, anti-diabetic, anti-tyrosinase, anti-neuro-degenerative and antimicrobial effects of five commercial preparations of FFTSS and two laboratories constituted mixtures. In-vitro 2, 2-diphenyl-1-picrylhydrazyl (DPPH), lipid peroxidation (LPO), α-glycosidase, tyrosinase, acetylcholinesterase, butyrylcholinesterase, elastase inhibitory and antimicrobial assays were carried out in order to determine the active potential of FFTSS. All commercial preparations have shown antioxidant properties after applying DPPH and LPO assays of an average IC50 of 117.68μg/ml and 2.86μg/ml, respectively. In addition, all commercial preparations exhibited a moderate inhibition against tyrosinase of an average IC50 of 0.353mg/ml while the activity were higher in the formula without salts and excipients reaching an IC50 of 0.077mg/ml. The anti-neurodegenerative property of FFTSS was weak while the inhibitory activity of elastase was stronger. The formula was able to inhibit α-glucosidase in an average of 60.22%. FFTSS showed stronger effect against Staphylococcus aureus but less antimicrobial activity against Gram-negative bacteria. In summary FFTSS has shown efficient scavenging effects of superoxide and peroxide radicals as well as a strong anti-inflammatory and anti-diabetic potential. Therefore the formulation can be considered as a valuable source of a natural antioxidant and anti-inflammatory, anti-diabetic and anti-aging agent but also as a candidate in the search for modern pharmaceuticals.
机译：中国古代的方方通神散（FFTSS）包含17个成分。这项研究的目的是研究5种市售FFTSS制剂和两个实验室组成的混合物的抗炎，抗氧化，抗糖尿病，抗酪氨酸酶，抗神经退行性和抗菌作用。为了确定FFTSS的活性潜能，进行了体外2,2-二苯基-1-吡啶并肼基（DPPH），脂质过氧化（LPO），α-糖苷酶，酪氨酸酶，乙酰胆碱酯酶，丁酰胆碱酯酶，弹性蛋白酶抑制和抗菌试验。所有商品制剂在进行DPPH和LPO分析后均显示出抗氧化性能，平均IC 50 分别为117.68μg/ ml和2.86μg/ ml。此外，所有商品制剂对酪氨酸酶的平均IC 50 表现出中等抑制作用，为0.353mg / ml，而配方中的活性更高，而盐和赋形剂均未达到IC 50 0.077mg / ml。 FFTSS的抗神经退行性较弱，而弹性蛋白酶的抑制活性较强。该配方能够平均抑制60.22％的α-葡萄糖苷酶。 FFTSS对金黄色葡萄球菌显示出更强的作用，但对革兰氏阴性菌的抗菌活性却更低。总之，FFTSS已显示出对超氧化物和过氧化物自由基的有效清除作用，以及强大的抗炎和抗糖尿病潜力。因此，该制剂可以被认为是天然抗氧化剂和抗炎剂，抗糖尿病药和抗衰老剂的宝贵来源，而且可以作为寻找现代药物的候选者。

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