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首页> 外文期刊>International Journal of Pharmaceutical Sciences and Research >ANTIDIABETIC EFFECT OF n-HEXANE FRACTION OF HYDRO-METHANOLIC EXTRACT OF TAMARINDUS INDICA LINN. SEED IN STREPTOZOTOCIN-INDUCED DIABETIC RAT: A CORRELATIVE APPROACH WITH IN VIVO AND IN VITRO ANTIOXIDANT ACTIVITIES
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ANTIDIABETIC EFFECT OF n-HEXANE FRACTION OF HYDRO-METHANOLIC EXTRACT OF TAMARINDUS INDICA LINN. SEED IN STREPTOZOTOCIN-INDUCED DIABETIC RAT: A CORRELATIVE APPROACH WITH IN VIVO AND IN VITRO ANTIOXIDANT ACTIVITIES

机译：塔玛琳达斯蜜的羟基甲醇提取物的正己烷馏分的抗抑菌作用。链脲佐菌素诱导的糖尿病大鼠种子中的体内和体外抗氧化剂活性的相关方法

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摘要

The present study was carried out to evaluate antidiabetic as well as in-vivo and in-vitro antioxidant activities of n-hexane fraction of Tamarindus indica Linn. seed (T. indica) in streptozotocin (STZ) induced diabetic rat. Oral administration of n-hexane fraction at the dose of 100 mg/kg body weight for 28 days prevented significantly the STZ-induced hyperglycemia. The plasma insulin and C-peptide levels as well as activities of antioxidant enzymes such as catalase (CAT), peroxidase (Px) and superoxide dismutase (SOD) in the hepatic tissue were found to be decreased in diabetic animals which were corrected after the treatment of n-hexane fraction of hydro-methanolic extract of T. indica. Oral glucose tolerance test (OGTT) reveals that the fraction at above mentioned dose showed a significant decrease of blood glucose level in normal and diabetic rat. Histopathology of pancreas was performed after n-hexane fraction treatment to diabetic rat and the results were compared with the control as well as diabetic groups. To evaluate the free radical scavenging activities of the n-hexane fraction following in-vitro study model with ABTS [2, 2′-azino-bis(3-ethyl benzothiazoline-6-sulphonic acid)] and DPPH [1, 1-diphenyl-2-picrylhydrazyl] were carried out along with determination of IC50 values 0.027±0.003 and 0.021±0.002 mg/ml respectively in respect to standard antioxidant such as butylated hydroxytoluene (BHT). Phytochemical studies reveal the presence of flavonoids, alkaloids, terpenoids and steroids in said fraction which is responsible for the possible antidiabetic and antioxidative actions. Acute toxicity study in rats did not show any signs of toxicity upto the dose of 3000 mg/kg body weight in rats.
机译：本研究旨在评估罗望子Ta的正己烷部分的抗糖尿病以及体内和体外的抗氧化活性。链脲佐菌素（STZ）诱导的糖尿病大鼠体内的种子（T. indica）。以100 mg / kg体重的剂量口服正己烷组分28天可显着预防STZ诱导的高血糖症。发现糖尿病动物肝脏组织中的血浆胰岛素和C肽水平以及抗氧化酶的活性（例如过氧化氢酶（CAT），过氧化物酶（Px）和超氧化物歧化酶（SOD））降低，在治疗后需要纠正。的水-甲醇提取物的正己烷馏分口服葡萄糖耐量试验（OGTT）显示，上述剂量的部分在正常和糖尿病大鼠中均显示血糖水平显着降低。在对大鼠进行正己烷馏分处理后，进行胰腺组织病理学检查，并将结果与​​对照组和糖尿病组进行比较。为了评估体外研究模型下ABTS [2，2'-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）]和DPPH [1，1-二苯基]的正己烷馏分的自由基清除活性相对于标准抗氧化剂（如丁基羟基甲苯（BHT）），分别测定-2-piclllhydrazyl和IC 50 的IC值0.027±0.003和0.021±0.002 mg / ml。植物化学研究表明，所述级分中存在类黄酮，生物碱，萜类化合物和类固醇，这可能与抗糖尿病和抗氧化作用有关。在大鼠中的急性毒性研究显示，直至大鼠3000 mg / kg体重的剂量，均未显示任何毒性迹象。

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