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首页> 外文期刊>International Journal of Pharmaceutical Sciences and Research >ANTIMICROBIAL ACTIVITY OF AQUEOUS AND ETHANOL EXTRACTS OF VIOLET PLANT (SECURIDACA LONGIPEDUNCULATA FRES) ON TESTED PATHOGENIC BACTERIA
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ANTIMICROBIAL ACTIVITY OF AQUEOUS AND ETHANOL EXTRACTS OF VIOLET PLANT (SECURIDACA LONGIPEDUNCULATA FRES) ON TESTED PATHOGENIC BACTERIA

机译：紫茎泽兰水生和乙醇提取物对致病菌的抑菌活性

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This study was undertaken to investigate the antimicrobial activities of aqueous and ethanol extracts of violet plant, Securideca longepedunculata leaves and root bark extracts against the pathogenic bacteria isolates of Salmonella typhi, Escherichia coli and Pseudomonas aeroginosa. Disc diffusion method was used for antibacterial testing and Tetracycline drug at 250 mg/ml concentration was used as positive reference standards to determine the sensitivity of the strains. The results of the antibacterial activities revealed that the highest growth inhibition of the tested bacteria was recorded as 8.00±1.00mm at 250 mg/ml, followed by 7.67±1.15mm at 250 mg/ml and the least inhibition was 3.00±2.00mm at 100 mg/ml. The minimum inhibitory concentrations for E. coli and S. typhi were 124 mg/ml and 250 mg/ml respectively. The results showed significant effect (P S. longepedunculata leaves and root bark extracts been used as potential antimicrobial agents in the management of microbial diseases caused by pathogenic bacteria species which may in turn be an alternative to chemical antibiotics. There is need to carry out sub-acute toxicity and determination of LD50 to isolate, identify, characterized and elucidate the structure of the bioactive compounds and mechanism of action of S. longepedunculata extracts against many pathogenic bacteria
机译：进行这项研究以研究紫罗兰植物的水和乙醇提取物，Securideca longepedunculata叶和根皮提取物对鼠伤寒沙门氏菌，大肠杆菌和铜绿假单胞菌的病原菌的抗菌活性。使用圆盘扩散法进行抗菌测试，以浓度为250 mg / ml的四环素药物作为阳性参照标准品，以确定菌株的敏感性。抗菌活性的结果表明，在250 mg / ml时，被测细菌的最高生长抑制记录为8.00±1.00mm，在250 mg / ml时记录为7.67±1.15mm，而在250mg / ml处抑制最小，为3.00±2.00mm。 100毫克/毫升。大肠杆菌和伤寒沙门氏菌的最小抑菌浓度分别为124 mg / ml和250 mg / ml。结果显示出显着效果（长假单胞菌叶和根皮提取物已被用作潜在病原菌，用于治疗由病原菌引起的微生物疾病，而微生物病原菌可能会替代化学抗生素。急性毒性和LD 50 的测定，以分离，鉴定，表征和阐明生物活性化合物的结构以及长链杜鹃提取物对多种病原菌的作用机理

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