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首页> 外文期刊>International Journal of Pharmaceutical Sciences Review and Research >Computational Identification and Structural Analysis of Deleterious Functional SNPS in CHN1 Gene Causing Duane Retraction Syndromeby Jincy Anna Jomy, Rao Sethumadhavan, India.
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Computational Identification and Structural Analysis of Deleterious Functional SNPS in CHN1 Gene Causing Duane Retraction Syndromeby Jincy Anna Jomy, Rao Sethumadhavan, India.

机译：印度杜安（Rao Sethumadhavan）的金西·安娜·乔米（Jincy Anna Jomy），计算了造成Duane缩回综合征的CHN1基因中有害功能性SNPS的计算鉴定和结构分析。

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Marine-derived fungi are a rich source of structurally diverse bioactive secondary metabolites with unprecedented skeletons and have shown various health beneficial biological activities. The fungus Aspergillus unguis RSPG_204 associated to the marine Sponge (Agelas sp., Red Sea , Egypt) was investigated. The supernatant and mycelial extracts [culture static (clt.st.)] had the highest free radical scavenging activity against superoxide anion radical. The mycelial extract (clt.st.) revealed significant acetyl cholinesterase inhibitory activity (47.5%). The supernatant (clt.st.) is the only one showed very low (3.6%) activity against tyrosinase while, it had a high α-glucosidase inhibitory activity (42.3%). The supernatant and mycelial extracts (culture shakes) had no biological activities. 55 compounds were identified by GC/MS analysis; 48 compounds in supernatant static (A) and 12 compounds in its mycelial extract (B). 8-Methoxy-5-methyl-2,3-dihydro-1-H-benzazepin-2-one (3.5%), 2-Piperidinone (1.6%), Benzoic acid (1.65%); Pyrimidine-2,4– dihydroxy (0.76%); 2,5-Diketopiperazine (0.25%), 3-Phenyl-3-hydoxypropanoic acid (0.5%), 4-Hydroxy Benzoic acid (1.38%), Benzeneacetic acid-4-hydroxy (1.29%), 9-Amino-3,3-dimethyl-3,4-dihydro-1(2H)acridone (0.4%), Kojic acid (2.3%), Hydrocinnamic acid, p-hydroxy (1.3%), N-Isopropyl-2-phenyl-6-pentanyl-4-pyridinamine (2.36%), Cinnamic acid-p-hydroxy (0.62%) were identified in (A). Hexadecanoic acid (5.91%), Heptadecanoic acid (0.61%), 9,12-Octadecadienoic acid (14.3%), 9-Octadecenoic acid (4.7%), Octadecanoic acid (2.22%), Octadecanoic acid-2,3-hydroxypropylester (0.62%), 2',4’-Diethoxy-6'-methoxy-3,4- methylenedioxychalcone (1.05%) were identified in (B). It could be concluded that, the fungus Aspergillus unguis RSPG_204 2ry metabolites showed significant acetyl cholinesterase and high α-glucosidase inhibition, beside its high antioxidant activities. Our study provides (for the first time) primary evidence suggesting that these 2ry metabolites in further in-vivo studies could play an important role as acetyl cholinesterase and α-glucosidase inhibitors, besides their antioxidant activities.
机译：海洋来源的真菌是具有前所未见的骨架的结构多样的生物活性次级代谢产物的丰富来源，并显示出各种有益健康的生物活性。研究了与海洋海绵（埃及红海的Agelas sp。）有关的真菌Aspergillus unguis RSPG_204。上清液和菌丝体提取物[培养物静电（抗静电）]对超氧阴离子自由基的清除能力最高。菌丝体提取物（clt.st.）显示出显着的乙酰胆碱酯酶抑制活性（47.5％）。上清液（cst.st.）是唯一显示出极低的抗酪氨酸酶活性的（3.6％），而它具有很高的α-葡萄糖苷酶抑制活性（42.3％）。上清液和菌丝体提取物（培养液）没有生物学活性。通过GC / MS分析鉴定出55种化合物;上清液中的48种化合物（A）和菌丝体提取物中的12种化合物（B）。 8-甲氧基-5-甲基-2,3-二氢-1-H-苯并ze庚因-2-一（3.5％），2-哌啶酮（1.6％），苯甲酸（1.65％）;嘧啶-2,4-二羟基（0.76％）; 2,5-二酮哌嗪（0.25％），3-苯基-3-羟基丙酸（0.5％），4-羟基苯甲酸（1.38％），苯乙酸-4-羟基（1.29％），9-氨基-3， 3-二甲基-3,4-二氢-1（2H）ac啶酮（0.4％），曲酸（2.3％），肉桂酸，对羟基（1.3％），N-异丙基-2-苯基-6-戊基-在（A）中鉴定出4-吡啶胺（2.36％），肉桂酸对羟基（0.62％）。十六烷酸（5.91％），十七烷酸（0.61％），9,12-十八碳二烯酸（14.3％），9-十八烯酸（4.7％），十八烷酸（2.22％），十八烷酸-2,3-羟丙基酯（在（B）中鉴定出0.62％），2′，4′-二乙氧基-6′-甲氧基-3，4-亚甲二氧基查耳酮（1.05％）。可以得出结论，真菌曲霉RSPG_204 2ry代谢产物除了具有高抗氧化活性外，还表现出显着的乙酰胆碱酯酶和高α-葡萄糖苷酶抑制作用。我们的研究（首次）提供了主要证据，表明在进一步的体内研究中，这2ry代谢产物除具有抗氧化活性外，还可以起乙酰胆碱酯酶和α-葡萄糖苷酶抑制剂的重要作用。

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