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首页> 外文期刊>International Journal of Pharmacological Research >Cross-cytotoxicity study of antimalarial drugs and traditional medicinal plants on Renal Cells
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Cross-cytotoxicity study of antimalarial drugs and traditional medicinal plants on Renal Cells

机译：抗疟药与传统药用植物对肾细胞的交叉细胞毒性研究

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Objective: The association of Artemisinin based combination therapy with herbal medicine seems to be a factor favouring the occurrence of serious adverse effects, hepatitis disorders and acute renal failure in particular. The aim of this study was to evaluate the cross- toxicity of these associations on renal cells. Methods: African green monkey kidney cells (VERO) were incubated with anti-malarial drugs and plant preparations. The products used were: Artesunate 100mg / amodiaquine 270mg (ASAQ) and artemether 80mg / lumefantrine 480mg (AL) , and Sida acuta and Enantia polycarpa at a concentration of 10 μg / ml. After 5 days of incubation, a cell count was performed using a haemocytometer. Results: ASAQ resulted in significant cell destruction compared to the control between Day2 (p 30% in the tubes treated with ASAQ and Sida acuta. Finally, cell destruction was statistically significant in tubes treated with the combination of antimalarial drugs and traditional plants compared to the control tube from Day2 (p <0.001). Conclusion: The renal toxicity observed with ASAQ, Sida acuta and combination of antimalarial drugs and herbs, appears dose-dependent or cumulative. The mechanism of this renal toxicity should be better analysed in further studies.
机译：目的：以青蒿素为基础的联合疗法与草药的结合似乎是导致严重不良反应，肝炎疾病和急性肾衰竭发生的一个因素。这项研究的目的是评估这些关联对肾细胞的交叉毒性。方法：将非洲绿猴肾细胞（VERO）与抗疟疾药物和植物制剂一起孵育。所用产品为：青蒿琥酯100mg /阿莫地喹270mg（ASAQ）和青蒿醚80mg / lumantantrine 480mg（AL）以及浓度为10μg/ ml的Sida acuta和Enantia polycarpa。温育5天后，使用血细胞计数器进行细胞计数。结果：与第2天之间的对照相比，ASAQ导致了显着的细胞破坏（在用ASAQ和Sida acuta处理的试管中，p占30％。最后，与用抗疟药和传统植物联合处理的试管中，细胞破坏在统计学上是显着的）从第2天开始的对照组（p <0.001）。结论：用ASAQ，Sida acuta以及抗疟药和草药的组合观察到的肾毒性表现出剂量依赖性或累积性，这种肾毒性的机制应进一步研究进一步分析。

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