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首页> 外文期刊>International Journal of Pharmacological Research >Antitussive properties of the root extract and fractions of Acanthospermum hispidum (L)
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Antitussive properties of the root extract and fractions of Acanthospermum hispidum (L)

机译：刺五加（L）根提取物和级分的镇咳特性

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Acanthospermum hispidum (Asteraceae) is plant widely used in South Eastern Nigeria to treat cough. This study investigated the antitussive properties of the root extract and fractions of A. hispidum . The antitussive effects of oral administration of 400 and 800 mg/kg of A. hispidum root methanol extract (ME), hexane (HF), ethyl acetate (EF) and methanol fractions (MF) were evaluated using sulphur (iv) oxide and ammonia induced cough models in mice. The extract and fractions were subjected to acute toxicity test, phytochemical analysis and HPLC finger printing. The extract and fractions of A. hispidum exhibited strong and significant antitussive effects in both cough models. The MF and EF exhibited significant ( p 5000 mg/kg in mice was established for the extract. Phytochemical analysis revealed the presence of saponins and flavonoids which may be responsible for its antitussive effects. Results revealed the antitussive property of A. hispidum and root which correlate to its ethnomedicinal use to relieve cough.
机译：Acanthospermum hispidum（菊科）是尼日利亚东南部广泛用于治疗咳嗽的植物。本研究考察了朝鲜蓟根提取物及其组分的镇咳性能。使用氧化硫（iv）和氨水评估了400和800 mg / kg的朝鲜蓟根甲醇提取物（ME），己烷（HF），乙酸乙酯（EF）和甲醇馏分（MF）的镇咳作用诱发小鼠咳​​嗽模型。对提取物和级分进行急性毒性试验，植物化学分析和HPLC指纹图谱。在两个咳嗽模型中，组青曲霉的提取物和级分均显示出强而显着的镇咳作用。 MF和EF表现出显着的（p 5000 mg / kg的小鼠建立提取物。植物化学分析显示皂苷和黄酮类化合物可能具有镇咳作用，结果揭示了A. hispidum和根的镇咳特性。与缓解咳嗽的人种疗法有关。

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