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首页> 外文期刊>International Journal of Pharmaceutical Sciences and Research >BIOCHEMICAL STUDIES ON THE EFFECT OF ETHANOLIC EXTRACTS OF TRICHOSANTHES DIOICA AND CLITORIA TERNATEA IN STREPTOZOTOCIN INDUCED DIABETIC MALE WISTAR RATS
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BIOCHEMICAL STUDIES ON THE EFFECT OF ETHANOLIC EXTRACTS OF TRICHOSANTHES DIOICA AND CLITORIA TERNATEA IN STREPTOZOTOCIN INDUCED DIABETIC MALE WISTAR RATS

机译：毛滴虫的乙醇提取物和中华白CLI的乙醇提取物在链脲佐菌素诱导的糖尿病雄性大鼠中的作用的生物化学研究

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To investigate the effect of ethanolic extracts of leaf and fruit of Trichosanthe dioica (T. dioica) and leaf of Clitoria ternatea (C. ternatea) on the biochemical parameters in streptozotocin (STZ) induced diabetic Wistar albino rats. Healthy male adult Albino rats of Wistar strain were randomly divided into eleven groups of six rats each were assigned into normal and diabetic groups (Group I to XI). Diabetes was induced in albino rats by administration of STZ (60 mg/kg i.p). Group I and II were kept as normal control and diabetic control. The other diabetic groups from group III to group X were treated with either individual and combined ethanolic extracts of T. dioica and C. ternatea at a dose of 200 and 400 mg/kg of body weight (bw) were administrated at a single dose per day and group XI was treated with glibenclamide at a dose of 600 μg/kg body weight for 28 consecutive days. The effect of ethanolic extracts of leaf and fruit of T. dioica and leaf of C. ternatea on blood glucose, serum insulin, glycosylated hemoglobin (HbA1c), urea, creatinine, SGOT, SGPT, LDH, ALP, total protein, albumin and globulin were evaluated in the diabetic rats. In the acute toxicity study, ethanolic extracts of leaf and fruit of T. dioica and leaf of C. ternatea were non-toxic and safe up to 2000 mg/kg body weight in rats. A significant decrease in blood glucose, HbA1c and other biochemical parameters levels and increase in serum insulin level were observed in diabetic rats treated with ethanolic extracts of T. dioica (leaf and fruit) and C. ternatea (leaf) compared to diabetic control rats. These findings suggest that the combined extract of T. dioica fruit and C. ternatea leaf have potent antidiabetic activity in STZ induced diabetic rats.
机译：目的研究天花粉虱（T. dioica）和三叶草柠檬酸（C. ternatea）的叶和果实的乙醇提取物对链脲佐菌素（STZ）诱导的糖尿病性维斯塔白化病大鼠生化指标的影响。将健康的Wistar雄性成年雄性白化大鼠随机分为11组，每组6只，分为正常组和糖尿病组（I至XI组）。通过给予STZ（60 mg / kg i.p），在白化病大鼠中诱发糖尿病。将I和II组保持为正常对照和糖尿病对照。从第III组到第X组的其他糖尿病组分别以200毫克/千克体重和400毫克/千克体重（bw）的剂量单独或联合使用丁二酸和叔丁酸乙醇提取物进行治疗，第11天，连续第28天用格列苯脲以600μg/ kg体重的剂量治疗。茶树叶和果实及茶树的乙醇提取物对血糖，血清胰岛素，糖基化血红蛋白（HbA1c），尿素，肌酐，SGOT，SGPT，LDH，ALP，总蛋白，白蛋白和球蛋白的影响在糖尿病大鼠中进行了评估。在急性毒性研究中，丁二酸叶和果实的乙醇提取物以及C. ternatea的叶对大鼠无毒且安全，最高至2000 mg / kg体重。与糖尿病对照大鼠相比，用丁二酸（叶和果实）和C.ternatea（叶）的乙醇提取物治疗的糖尿病大鼠，血糖，HbA1c和其他生化参数水平显着降低，血清胰岛素水平明显升高。这些发现表明，T.dioica果实和C.ternatea叶的联合提取物在STZ诱导的糖尿病大鼠中具有有效的抗糖尿病活性。

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