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首页> 外文期刊>International Journal of Preventive Medicine >CYTOMEGALOVIRUS, TOXOPLASMA GONDII AND RUBELLA VERTICAL TRANSMISSION RATES ACCORDING TO MID?TRIMESTER AMNIOCENTESIS: A RETROSPECTIVE STUDY
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CYTOMEGALOVIRUS, TOXOPLASMA GONDII AND RUBELLA VERTICAL TRANSMISSION RATES ACCORDING TO MID?TRIMESTER AMNIOCENTESIS: A RETROSPECTIVE STUDY

机译：中三角羊膜穿刺术引起的巨细胞病毒，弓形虫和RUBELLA垂直传播率的回顾性研究

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Objective: To examine vertical transmission rates of Cytomegalovirus, Toxoplasma Gondii and Rubella infections according to amniotic fluid PCR analysis.Methods: A retrospective analysis of mid-trimester amniocenteses performed in in pregnancies with diagnosed maternal infection by Cytomegavirus (CMV), Rubella or Toxoplasma gondii during 1994-2008 was performed. Vertical transmission rates were observed according to the presence of the infectious agent’s DNA in the amniotic fluid. A univariate regression model was also performed to investigate possible correlations between transmission and epidemiological parameters.Results: Overall, 7033 amniocenteses were performed during study’s period, of which 166 (2.4%) with the indication of maternal infection by CMV, Rubella or Toxoplasma. Mean maternal age was 27.4 ± 2.5 years and the mean gestational age at amniocentesis was 18.7±2.5 weeks. Vertical transmission was observed in 21 cases (12.7%). Transmission rate was 17.3% in cases with infection from CMV, 9.5% from Toxoplasma gondii and 7.8% from Rubella (P=.05). Maternal age was the only parameter being significantly associated with increased risk for vertical transmission (P=.04).Conclusions: According to our results, overall vertical transmission rate marginally exceeds 10%. CMV infection is characterized by relatively higher transplacental transmission rate, while increased maternal age appears to be associated with a higher risk for vertical transmission.
机译：目的：通过羊水PCR分析检查巨细胞病毒，弓形虫和风疹感染的垂直传播率。方法：对诊断为母体感染巨细胞病毒（CMV），风疹或弓形虫的妊娠中期中期羊膜穿刺术进行回顾性分析。在1994年至2008年期间进行。根据羊水中存在的传染原DNA，观察到垂直传播速率。结果：总体上，研究期间进行了7033例羊膜穿刺术，其中166例（2.4％）表现为母亲感染了CMV，风疹或弓形虫。产妇平均年龄为27.4±2.5岁，羊膜穿刺术的平均胎龄为18.7±2.5周。垂直传播21例（12.7％）。感染CMV的患者的传播率为17.3％，弓形虫的传播率为9.5％，风疹的传播率为7.8％（P = .05）。产妇年龄是与垂直传播风险增加显着相关的唯一参数（P = .04）。结论：根据我们的结果，总体垂直传播率略高于10％。 CMV感染的特点是胎盘传播速度相对较高，而产妇年龄的增加似乎与垂直传播的风险较高有关。

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