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首页> 外文期刊>International Journal of Preventive Medicine >EFFECT OF VITAMIN E ON OXALIPLATIN?INDUCED PERIPHERAL NEUROPATHY PREVENTION: A RANDOMIZED CONTROLLED TRIAL
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EFFECT OF VITAMIN E ON OXALIPLATIN?INDUCED PERIPHERAL NEUROPATHY PREVENTION: A RANDOMIZED CONTROLLED TRIAL

机译：维生素E对草酸磷脂诱导的周围神经病预防的作用：随机对照试验

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Background: Peripheral neuropathy is one of the most important limitations of oxaliplatin base regimen, which is the standard for the treatment of colorectal cancer. Evidence has shown that Vitamin E may be protective in chemotherapy ? induced peripheral neuropathy. The aim of thisstudy is to evaluate the effect of Vitamin E administration on prevention of oxaliplatin ? induced peripheral neuropathy in patients with colorectal cancer.Methods: This was a prospective randomized, controlled clinical trial. Patients with colorectal cancer and scheduled to receive oxaliplatin ? based regimens were enrolled in this study. Enrolled patients were randomized into two groups. The first group received Vitamin E at a dose of 400mg daily and the second group observed, until after the sixth course of the oxaliplatin regimen. For oxaliplatin ? induced peripheral neuropathy assessment, we used the symptom experience diary questionnaire that completed at baseline and after the sixth course of chemotherapy. Only patients with a score of zero at baseline were eligible for this study.Results: Thirty ? two patients were randomized to the Vitamin E group and 33 to the control group. There was no difference in the mean peripheral neuropathy score changes(after-before) between two groups, after sixth course of the oxaliplatin base regimen (mean difference [after- before] of Vitamin E group= 6.37±2.85, control group= 6.57 ± 2.94; P=0.78). Peripheral neuropathy scores were significantly increased after intervention compared with a base line in each group (PConclusions: The results from this current trial demonstrate a lack of benefit for Vitamin E in preventing oxaliplatin ? induced peripheral neuropathy.
机译：背景：周围神经病变是奥沙利铂基础治疗方案的最重要局限之一，奥沙利铂基础治疗方案是治疗结直肠癌的标准。有证据表明维生素E在化疗中可能具有保护作用？引起周围神经病变。本研究的目的是评估维生素E给药对预防奥沙利铂的作用？方法：这是一项前瞻性随机对照临床试验。大肠癌患者并计划接受奥沙利铂治疗基于基础的方案被纳入这项研究。入组患者被随机分为两组。第一组每天接受400mg剂量的维生素E，观察第二组，直到奥沙利铂方案的第六个疗程结束。对于奥沙利铂？诱发的周围神经病变评估，我们使用了在基线和化疗第六次疗程后完成的症状经验日记调查表。只有基线评分为零的患者才有资格参加本研究。两名患者被随机分为维生素E组和33名对照组。在奥沙利铂基础方案第六疗程后，两组之间（前后）的平均周围神经病评分变化无差异（维生素E组的平均差异[前后] = 6.37±2.85，对照组= 6.57±） 2.94; P = 0.78）。与每组的基线相比，干预后的周围神经病变评分显着增加（PConclusions：本试验的结果表明，维生素E在预防奥沙利铂？引起的周围神经病变方面缺乏益处。

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