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首页> 外文期刊>International Journal of Preventive Medicine >The Protective Effect of γ-aminobutyric Acid on Kidney Injury Induced by Renal Ischemia-reperfusion in Ovariectomized Estradiol-treated Rats
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The Protective Effect of γ-aminobutyric Acid on Kidney Injury Induced by Renal Ischemia-reperfusion in Ovariectomized Estradiol-treated Rats

机译：γ-氨基丁酸对去卵巢雌二醇治疗大鼠肾脏缺血再灌注所致肾脏损伤的保护作用

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Background: Renal ischemia-reperfusion injury (IRI) is one of the most important causes of kidney injury, which is possibly gender-related. This study was designed to investigate the role of γ-aminobutyric acid (GABA) against IRI in ovariectomized estradiol-treated rats. Methods: Thirty-five ovariectomized Wistar rats were used in six experimental groups. The first three groups did not subject to estradiol treatment and assigned as sham-operated, control, and GABA-treated groups. GABA (50 μmol/kg) and saline were injected in the treated and control groups 30 min before the surgery, respectively. The second three groups received the same treatments but received estradiol valerate (500 μg/kg, intramuscularly) 3 days prior to the surgery. The IRI was induced in the control and treated groups by clamping the renal artery for 45 min and then 24 h of reperfusion. All animals were sacrificed for the measurements. Results: The serum levels of creatinine and blood urea nitrogen, kidney weight, and kidney tissue damage score significantly increased in the IRI rats ( P 0.05). GABA significantly decreased the aforementioned parameters ( P 0.05). The uterus weight increased significantly in rats that received estradiol ( P 0.05). Serum and kidney levels of nitrite (nitric oxide metabolite) did not alter significantly. Serum level of malondialdehyde increased significantly in the ovariectomized rats exposed to IRI ( P 0.05). Conclusions: It seems that GABA improved IRI in ovariectomized rats. Estradiol was also nephroprotective against IRI. However, co-administration of estradiol and GABA could not protect the kidney against IRI.
机译：背景：肾脏缺血再灌注损伤（IRI）是肾脏损伤的最重要原因之一，可能与性别有关。本研究旨在研究在去卵巢雌二醇治疗的大鼠中，γ-氨基丁酸（GABA）对IRI的作用。方法：将35只卵巢切除的Wistar大鼠用于六个实验组。前三组未接受雌二醇治疗，分为假手术组，对照组和GABA治疗组。手术前30分钟分别在治疗组和对照组中注射GABA（50μmol/ kg）和生理盐水。后三组接受相同的治疗，但在手术前3天接受戊酸雌二醇（500μg/ kg，肌肉注射）。在对照组和治疗组中，将肾动脉钳夹45分钟，然后再灌注24小时，从而诱发IRI。处死所有动物以进行测量。结果：IRI大鼠血清肌酐和血尿素氮水平，肾脏重量和肾脏组织损伤评分显着升高（P <0.05）。 GABA显着降低了上述参数（P <0.05）。接受雌二醇的大鼠子宫重量显着增加（P <0.05）。血清和肾脏中亚硝酸盐（一氧化氮代谢物）的水平没有明显改变。暴露于IRI的去卵巢大鼠的血清丙二醛水平显着增加（P <0.05）。结论：GABA似乎可以改善去卵巢大鼠的IRI。雌二醇对IRI也具有肾保护作用。但是，雌二醇和GABA并用不能保护肾脏抵抗IRI。

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