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首页> 外文期刊>International Journal of Preventive Medicine >Relation between Body Iron Status and Cardiovascular Risk Factors in Patients with Cardiovascular Disease
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Relation between Body Iron Status and Cardiovascular Risk Factors in Patients with Cardiovascular Disease

机译：心血管疾病患者体内铁含量与心血管危险因素的关系

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Background: There is conflicting evidence regarding the relationship between iron stores and cardiovascular disease (CVD). The present study aimed to investigate the association between body iron indices and some cardiovascular risk factors. Methods: In a case–control study conducted in the south of Shiraz, Iran, we determined ferritin, iron, total iron binding capacity (TIBC), metabolic risk factors, C-reactive protein (CRP), and anthropometric measurements in 100 men aged 45 years and higher with newly diagnosed CVD and 100 adjusted controls without evidence for CVD. Results: The mean of low density lipoprotein (LDL-c), CRP, and ferritin concentrations were significantly higher in cases than controls, and high density lipoprotein (HDL-c) was significantly lower in cases than controls. Pearson correlation coefficient between CRP and the other risk factors in case group showed that only ferritin, serum iron, waist circumference, and LDL-c significantly correlated with CRP ( r = 0.32 with P 0.001, r = 0.29 with P 0.05, r = 0.41 with P 0.01, and r = 0.36 with P 0.001, respectively). Conclusions: This study indicated an association between a positive balance of body iron and CVD. Hence, caution should be exercised in administration of iron supplements to patients with CVD and in consumption of food rich in iron by them.
机译：背景：关于铁存储与心血管疾病（CVD）之间关系的证据相互矛盾。本研究旨在调查人体铁指数与某些心血管危险因素之间的关系。方法：在伊朗设拉子南部进行的病例对照研究中，我们确定了100名年龄在男性中的铁蛋白，铁，总铁结合能力（TIBC），代谢危险因素，C反应蛋白（CRP）和人体测量患有新诊断的CVD的患者为45岁及以上，以及100名没有CVD证据的调整对照。结果：病例中低密度脂蛋白（LDL-c），CRP和铁蛋白浓度的平均值显着高于对照组，而病例中高密度脂蛋白（HDL-c）显着低于对照组。病例组中CRP与其他危险因素之间的Pearson相关系数表明，只有铁蛋白，血清铁，腰围和LDL-c与CRP显着相关（r = 0.32，P <0.001，r = 0.29，P <0.05，r当P <0.01时= 0.41;当P <0.001时r = 0.36）。结论：这项研究表明体内铁与CVD的正平衡之间存在关联。因此，在向患有CVD的患者服用铁补充剂以及由他们食用富含铁的食物时应谨慎行事。

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