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首页> 外文期刊>International Journal of Preventive Medicine >Effects of Pure Eicosapentaenoic and Docosahexaenoic Acids on Oxidative Stress, Inflammation and Body Fat Mass in Patients with Type 2 Diabetes
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Effects of Pure Eicosapentaenoic and Docosahexaenoic Acids on Oxidative Stress, Inflammation and Body Fat Mass in Patients with Type 2 Diabetes

机译：纯二十碳五烯酸和二十二碳六烯酸对2型糖尿病患者氧化应激，炎症和体脂量的影响

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Background: N-3 Fatty acids reduce the risk of cardiovascular disease. Previous studies have shown that they may reduce inflammation, oxidative stress, and fat mass in patients with type 2 diabetes, but the results are inconclusive, due, in part, to type of omega-3 fatty acids used. The aim of this study was to determine the effects of pure eicosapentaenoic (EPA) and docosahexaenoic acids (DHA), the two major omega-3 fatty acids, on inflammation, oxidative stress, and fat mass in patients with type 2 diabetes. Methods: Sixty patients with DM-II were randomly allocated to receive daily either ~1 gr EPA or ~1 gr DHA, or a canola oil as placebo for 12 weeks in a randomized triple-blind, placebo-controlled trial. Serum MDA, CRP, body weight, BMI, and fat mass were measured at baseline and after intervention. Results: Forty-five patients with a mean (±SD) age of 54.9 ± 8.2 years with BMI of 27.6 ± 4.1 kg/m2 and fasting blood glucose 96.0 ± 16.2 mg/dl completed the intervention. Neither EPA nor DHA had significant effects on serum FBS, C-reactive protein, body weight, BMI, and fat mass after intervention ( P 0.05). In addition, while MDA increased 18% in the placebo group ( P = 0.009), it did not change in the EPA or DHA group ( P 0.05). Conclusions: Twelve weeks of supplementation with 1gr/d EPA or DHA prevent increasing oxidative stress without changing marker of inflammation. This study is the first report demonstrating that neither EPA nor DHA have effects on body fat mass in type 2 diabetic patients.
机译：背景：N-3脂肪酸可降低罹患心血管疾病的风险。先前的研究表明，它们可以减轻2型糖尿病患者的炎症，氧化应激和脂肪量，但结果尚不确定，部分原因是所用的omega-3脂肪酸类型。这项研究的目的是确定纯的二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）这两种主要的omega-3脂肪酸对2型糖尿病患者的炎症，氧化应激和脂肪量的影响。方法：在一项随机的三盲，安慰剂对照试验中，将60名DM-II患者随机分配至每天接受〜1 gr EPA或〜1 gr DHA或低芥酸菜子油作为安慰剂，为期12周。在基线和干预后测量血清MDA，CRP，体重，BMI和脂肪量。结果：45位平均（±SD）年龄为54.9±8.2岁，BMI为27.6±4.1 kg / m2和空腹血糖96.0±16.2 mg / dl的患者完成了干预。干预后，EPA和DHA对血清FBS，C反应蛋白，体重，BMI和脂肪量均无显着影响（P> 0.05）。此外，安慰剂组的MDA增加了18％（P = 0.009），而EPA或DHA组的MDA没有变化（P> 0.05）。结论：补充1gr / d EPA或DHA的十二周可防止氧化应激增加，而不会改变炎症标记。这项研究是第一个证明EPA和DHA都不对2型糖尿病患者的体内脂肪量产生影响的报告。

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