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Vinca Alkaloids

机译：长春花生物碱

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Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects. They have been used to treat diabetes, high blood pressure and have been used as disinfectants. The vinca alkaloids are also important for being cancer fighters. There are four major vinca alkaloids in clinical use: Vinblastine (VBL), vinorelbine (VRL), vincristine (VCR) and vindesine (VDS). VCR, VBL and VRL have been approved for use in the United States. Vinflunine is also a new synthetic vinca alkaloid, which has been approved in Europe for the treatment of second-line transitional cell carcinoma of the urothelium is being developed for other malignancies. Vinca alkaloids are the second-most-used class of cancer drugs and will stay among the original cancer therapies. Different researches and studies for new vinca alkaloid applications will be carried out in this regard.
机译：长春花生物碱是从马达加斯加长春花植物获得的药物的子集。它们是从粉红色的长春花植物Catharanthus roseus G. Don中自然提取的，具有降血糖和细胞毒性作用。它们已被用于治疗糖尿病，高血压并已被用作消毒剂。长春花生物碱对于抵抗癌症也很重要。临床上有四种主要的长春花生物碱：长春碱（VBL），长春瑞滨（VRL），长春新碱（VCR）和长春地辛（VDS）。 VCR，VBL和VRL已获准在美国使用。长春氟宁也是一种新的合成长春花生物碱，已在欧洲被批准用于治疗尿路上皮二线移行细胞癌，目前正在开发用于其他恶性肿瘤的药物。长春花生物碱是第二大类的抗癌药物，将保留在原始的癌症治疗方法中。在这方面，将针对长春花生物碱的新应用进行不同的研究。

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