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Skew-symmetric Random Effect Models with Application to a Preventive Cohort Study: Improving Outcomes in Low Back Pain Patients

机译:偏对称随机效应模型在预防性队列研究中的应用:改善腰痛患者的治疗效果

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Background: To investigate the respective contribution of various biologic and psychosocial factors, especially Health Related Quality of Life (HRQOL) as a main outcome, in the natural history of acute low back pain (LBP) and to evaluate the impact of this condition on HRQOL. Methods: In a prospective cohort study For 24 weeks, 150 patients were assessed at an outpatient clinic in Korea consulting for low back and confirmed disc herniation duration at inclusion and treated with treatment package comprised of herbal medicines, acupuncture, bee venom acupuncture, and a Korean version of spinal manipulation (Chuna). Study participants were evaluated at baseline and every 4 weeks for 24 weeks. Low back intensity levels were measured on a visual analog scale (0-10), back function was evaluated with the Oswestry Disability Index (0-100), disability assessed by HRQOL assessed by the short form 36 health survey (0-100 in 8 different sub-categories). Results: Out of 150 patients, 128 completed the 24 weeks of traditional therapy. Patients reported improvements SF-36 outcome measures. At the completion of the study, low back pain scores improved by a mean of 3.3 (95% CI = 2.8 to 3.8). According to the results of our modeling, low back intensity level, back function and BMI measures had significant effects on quality of life during study. Interpreting the coefficients of modeling, the impact of the decreasing acute LBP episode on HRQOL by VAS and ODI outcomes, was high and important. Conclusions: This study highlights the large contribution of integrative package therapy as an effective preventive method for improving LBP patient's HRQOL.
机译:背景:研究急性下背痛(LBP)的自然史中各种生物学和社会心理因素(尤其是与健康有关的生活质量(HRQOL)作为主要结果)的各自贡献,并评估这种情况对HRQOL的影响。方法:在一项前瞻性队列研究中,为期24周,在韩国的一家门诊诊所对150例患者进行了评估,评估其腰背部情况,并确认纳入时的椎间盘突出持续时间,并用包括草药,针灸,蜂毒针灸和韩版脊柱操纵(Chuna)。在基线和每4周评估一次研究参与者,持续24周。在视觉模拟量表(0-10)上测量低背强度水平,用Oswestry残疾指数(0-100)评估背功能,通过HRQOL评估残障,通过简短的36健康调查评估(8中为0-100)不同的子类别)。结果:在150名患者中,有128名完成了24周的传统疗法。患者报告了SF-36结果指标的改善。研究完成后,腰背痛评分平均提高了3.3(95%CI = 2.8至3.8)。根据我们的建模结果,低背强度水平,背部功能和BMI措施对研究过程中的生活质量有重大影响。解释模型的系数,通过VAS和ODI结果得出的急性LBP发作减少对HRQOL的影响非常重要。结论:本研究强调了综合包装疗法作为改善LBP患者HRQOL的有效预防方法的巨大贡献。

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