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首页> 外文期刊>International Journal of Preventive Medicine >Is There Any Difference Between Preeclamptic and Healthy Pregnant Women Regarding the Presence of Periopathogenic Bacteria in the Placenta?
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Is There Any Difference Between Preeclamptic and Healthy Pregnant Women Regarding the Presence of Periopathogenic Bacteria in the Placenta?

机译：子痫前期和健康孕妇在胎盘中是否存在致病性细菌方面有什么区别？

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Background: Preeclampsia is an important cause of maternal morbidity and mortality with unclear cause. It is believed that inflammation plays an important role in the pathogenesis of preeclampsia. Periodontal disease is a chronic inflammatory infectious condition which commonly involves humans. Recently, chronic infection was linked to atherosclerosis. Atherosclerosis shares some histopathologic features with uteroplacental atherosis of preeclamptic women. This study was aimed to investigate the presence of periopathogenic bacteria in the placental tissue of preeclamptic women, and compare it with women with normal pregnancy. Methods: Samples were obtained from 23 placentas of preeclamptic women and from 23 age-matched healthy pregnant women. Qualitative polymerase chain reaction was performed to detect the presence of five periopathogenic bacteria. Results: There was no significant difference between the two groups regarding the relative frequency of women with different types of periopathogenic bacterial infection of the placenta. In addition, there was no significant difference in the number of women with any type of infection of the placenta (regardless of the type of periopathogenic bacteria) [14 (61%) mothers with placental infection in the case group vs. 18 (78%) mothers in the control group, P value = 0.16]. Conclusions: This study did not show any significant difference between preeclamptic women and healthy women with normal pregnancy regarding the periopathogenic bacterial profile of the placenta.
机译：背景：先兆子痫是孕产妇发病和死亡的重要原因，原因尚不清楚。据信炎症在先兆子痫的发病机理中起重要作用。牙周疾病是一种慢性炎性感染性疾病，通常涉及人类。最近，慢性感染与动脉粥样硬化有关。子痫前期妇女的动脉粥样硬化与子宫胎盘动脉粥样硬化有一些组织病理学特征。这项研究旨在调查先兆子痫妇女胎盘组织中的致病菌，并将其与正常妊娠妇女进行比较。方法：从23名先兆子痫妇女的胎盘和23名年龄匹配的健康孕妇中获取样本。进行定性聚合酶链反应以检测5种致病菌的存在。结果：两组在胎盘病原菌感染类型不同的女性相对频率上没有显着差异。此外，在任何类型的胎盘感染中（不论致病菌的种类如何），女性数量均无显着差异[病例组中有14名妇女（61％）有胎盘感染，而18名妇女（78％） ）对照组的母亲，P值= 0.16]。结论：这项研究在子痫前期妇女和正常妊娠的健康妇女之间未发现胎盘的病因病原菌特征有任何显着差异。

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