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首页> 外文期刊>International Journal of Pharmaceutical Sciences and Research >EVALUATION OF CIPROFLOXACIN EFFECT ON THE ANTIMALARIAL ACTIVITY OF SOME ANTIMALARIAL DRUGS IN PLASMODIUM BERGHEI INFECTED MICE
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EVALUATION OF CIPROFLOXACIN EFFECT ON THE ANTIMALARIAL ACTIVITY OF SOME ANTIMALARIAL DRUGS IN PLASMODIUM BERGHEI INFECTED MICE

机译：环丙沙星对伯氏疟原虫感染小鼠某些抗风湿药抗风湿活性的评价

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This study evaluates the effect of ciprofloxacin (CIP) on the antimalarial activity of artesunate (AS), artemether-lumefantrine (AL) and artesunate-amodiaquine using animal model. Some 120 albino mice infected with chloroquine sensitive Plasmodium berghei NK65 strain were used. The study was carried out in three phases. Phase 1 consisted of eleven groups treated with different doses of either AS, AL, ASAQ or CIP alone. Phase 2 consisted of nine groups treated with 7 mg/kg of CIP (CIP1) combined with different doses of AS, AL, ASAQ. Phase 3 consist of ten groups treated with 14 mg/kg of CIP (CIP2) with different doses of AS, AL, ASAQ. Thin blood films were used to assess parasitemia level daily after administration of drugs for 72 h. Results were analyzed using student t-test and analysis of variance (ANOVA). CIP alone showed antimalarial activity with 63 % parasitemia reduction. Antimalarial activities of AS and AL were significantly enhanced by both 7 and 14 mg/kg of CIP. The antimalarial effect of ASAQ was enhanced but not statistically significant. Low dose ciprofloxacin significantly enhanced the antimalarial activities of Artesunate, Artemether-Lumefanthrine and Artesunate-Amodiaquine This combination may be beneficial in the management of Plasmodium falciparum infection or co-infection with salmonellosis
机译：这项研究使用动物模型评估了环丙沙星（CIP）对青蒿琥酯（AS），青蒿琥酯-荧光黄素（AL）和青蒿琥酯-氨二喹的抗疟活性的影响。使用了约120只感染了氯喹敏感性伯氏疟原虫NK65株的白化病小鼠。该研究分三个阶段进行。第1阶段由11组组成，分别接受不同剂量的AS，AL，ASAQ或CIP治疗。第二阶段包括九组，分别接受7 mg / kg的CIP（CIP1）和不同剂量的AS，AL，ASAQ治疗。第三阶段包括十组，分别用14 mg / kg的CIP（CIP2）和不同剂量的AS，AL，ASAQ治疗。给药72小时后，每天使用薄血膜评估寄生虫血症水平。使用学生t检验和方差分析（ANOVA）分析结果。仅CIP表现出抗疟活性，寄生虫血症减少63％。 7和14 mg / kg的CIP可以显着增强AS和AL的抗疟活性。 ASAQ的抗疟作用增强，但无统计学意义。低剂量环丙沙星显着增强了青蒿琥酯，青蒿琥酯-美沙芬和青蒿琥酯-阿莫地喹的抗疟药活性

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