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首页> 外文期刊>International Journal of Pharmacological Research >Ornithine aspartate attenuates thioacetamide induced hepatic encephalopathy through GABA-benzodiazepine receptors
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Ornithine aspartate attenuates thioacetamide induced hepatic encephalopathy through GABA-benzodiazepine receptors

机译：鸟氨酸天冬氨酸通过GABA-苯并二氮杂receptor受体减轻硫代乙酰胺诱发的肝性脑病

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The aim for this study was to investigate the effect of L-ornithine-L-aspartate (OA) in combination with benzodiazepine agonist (diazepam) and antagonist (flumazenil) in thioacetamide (TAA) induced hepatic encephalopathy (HE) in mice. HE was induced in mice by administration of TAA (25mg/kg, i.p.) thrice at 24 hours interval. OA (2gm/kg, p.o.), diazepam (4mg/kg, i.p.) and flumazenil (5mg/kg, i.p.) were administered in different combinations along with TAA and the mice were observed for motor activity, grip strength, traction test and mortality. TAA administration produced stage II – III of HE in mice with highly significant reduction in motor activity. OA protected the animals significantly in TAA and TAA plus diazepam treated groups as was done by flumazenil. Taken together, the findings of the present study suggest that OA actions in TAA induced HE in mice may be mediated through GABA-benzodiazepine receptors.
机译：这项研究的目的是研究L-鸟氨酸-L-天冬氨酸（OA）与苯二氮卓激动剂（diazepam）和拮抗剂（flumazenil）联合使用对乙硫胺（TAA）诱发的肝性脑病（HE）的作用。通过在24小时间隔内三次施用TAA（25mg / kg，腹膜内）诱导小鼠HE。将OA（2gm / kg，口服），地西epa（4mg / kg，腹膜内）和氟马西尼（5mg / kg，腹膜内）与TAA组合使用，并观察小鼠的运动活动，抓地力，牵引力测试和死亡率。 TAA给药在小鼠中产生了HE的II-III期，运动活性大大降低。 OA与氟马西尼一样，在TAA和TAA加地西epa治疗组中显着保护动物。综上所述，本研究的发现表明，TAA诱导的小鼠HE中的OA作用可能是通过GABA-苯并二氮杂receptor受体介导的。

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