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首页> 外文期刊>Infectious diseases in obstetrics and gynecology >Pregnancy Outcomes of Mothers with Detectable CMV-Specific IgM Antibodies: A Three-Year Review in a Large Irish Tertiary Referral Maternity Hospital
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Pregnancy Outcomes of Mothers with Detectable CMV-Specific IgM Antibodies: A Three-Year Review in a Large Irish Tertiary Referral Maternity Hospital

机译：具有可检测到的CMV特异性IgM抗体的母亲的妊娠结局：爱尔兰大型三级转诊产科医院的三年回顾

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A retrospective audit was performed for all obstetric patients who had positive CMV IgM results between January 2012 and December 2014 in the Rotunda Hospital, Ireland. In total, 622 CMV IgM positive tests were performed on samples from 572 patients. Thirty-seven patients had a positive CMV IgM result (5.9%) on the Architect system as part of the initial screening. Three patients were excluded as they were not obstetric patients. Of the 34 pregnant women with CMV IgM positive results on initial screening, 16 (47%) had CMV IgM positivity confirmed on the second platform (VIDAS) and 18 (53%) did not. In the 16 patients with confirmed positive CMV IgM results, four (25%) had acute infection, two (12.5%) had infection of uncertain timing, and ten (62.5%) had infection more than three months prior to sampling as determined by the CMV IgG avidity index. Two of the four neonates of women with low avidity IgG had CMV DNA detected in urine. Both these cases had severe neurological damage and the indication for testing their mothers was because the biparietal diameter (BPD) was less than the 5th centile at the routine 20-week gestation anomaly scan.
机译：在2012年1月至2014年12月期间，对爱尔兰Rotunda医院的所有CMV IgM结果均为阳性的产科患者进行了回顾性审核。总共对572位患者的样本进行了622次CMV IgM阳性测试。作为初始筛选的一部分，在Architect系统上，三十七名患者的CMV IgM结果阳性（5.9％）。由于三名患者不是产科患者，因此被排除在外。在最初筛查的CMV IgM阳性结果的34例孕妇中，有16例（47％）在第二个平台（VIDAS）上证实了CMV IgM阳性，而18例（53％）没有。在16例确诊为CMV IgM阳性的患者中，有4例（25％）患有急性感染，2例（12.5％）患有时间不确定的感染，10例（62.5％）的感染在采样前三个月以上。 CMV IgG亲和力指数。 IgG抗体含量低的四名新生儿中，有两名在尿液中检测到CMV DNA。这两种情况均具有严重的神经系统损害，并且对母亲进行检查的指征是因为在常规的20周妊娠异常扫描中双顶径（BPD）小于第5个百分位数。

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