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首页> 外文期刊>International Journal of Pharmacology >Analgesic Efficacy, Quality and Safety of “Sarenta”: An Herbal Preparation from Ivorian Traditional Medicine
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Analgesic Efficacy, Quality and Safety of “Sarenta”: An Herbal Preparation from Ivorian Traditional Medicine

机译：“ Sarenta”的镇痛功效，质量和安全性：科特迪瓦传统药物的草药制剂

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Background: Sarenta a decoction from medicinal plants was prepared by a traditional health practitioner. However, there is no scientific data that can back up its reliability for consumers. The main objective of the study was to evaluate the know-how of Ivoirian’s traditional health practitioners. Objective: The aim of this study was to carry out an ethnopharmacological survey about Sarenta, evaluate its analgesic activity, its quality through research of microbial contamination and eventually assess its acute toxicity. Materials and Methods: The ethnopharmacological survey was performed using an open questionnaire. The analgesic activity assessment through behavioral tests, abdominal constriction test in mice and formaldehyde-induced paw oedema test in rats. Thus, the microbial enumeration test based on the French pharmacopoeia and toxicity test 423 of Organization for Economic Cooperation and Development, helped to respectively evaluate microbial contamination and acute toxicity. Statistical test was performed using Wilcoxon test to compare groups. Results: The recommended dose set up by the traditional health practitioner was about 3 mg kg–1 b.wt. for adults. “Sarenta” at a dose of 5.10–8 mg kg–1 b.wt. (a preparation of 50 mg mL–1 was diluted to 10 millionth leading to 5.10–7 mg mL–1, which was administered to rats at 1 mL/100 g b.wt.) inhibited abdominal constrictions in mice by 76% and licking of injected paw in rat by 70% at the inflammatory phase. Therefore, no fecal contamination germ, no yeast and mold were found beyond the French pharmacopoeia standards. Moreover, no deaf of rat was recorded at a dose of 5000 mg kg–1. Conclusion: “Sarenta” exhibited analgesic and potential anti-inflammatory properties, a microbiological quality that complied with the French pharmacopoeia standards and contains no acute toxic substance. Thus, this first scientific study on herbal preparation could promote the know-how and professional practice of Ivoirian’s traditional health practitioners.
机译：背景：Sarenta一种由药用植物制成的汤剂是由传统的保健医生准备的。但是，没有科学数据可以支持其对消费者的可靠性。这项研究的主要目的是评估科特迪瓦传统保健人员的专业知识。目的：本研究的目的是对Sarenta进行民族药理学调查，通过研究微生物污染来评估其镇痛活性和质量，并最终评估其急性毒性。材料和方法：使用开放式问卷调查进行民族药理学调查。通过行为测试，小鼠腹部收缩测试和大鼠甲醛诱发的爪水肿测试来评估镇痛活性。因此，基于法国药典的微生物计数试验和经济合作与发展组织的毒性试验423有助于分别评估微生物污染和急性毒性。使用Wilcoxon检验进行统计学检验以比较各组。结果：传统保健医生设定的推荐剂量约为3 mg kg-1b.wt。对于成年人。 “ Sarenta”剂量为5.10–8 mg kg–1b.wt。 （将50 mg mL–1的制剂稀释至1百万分之一，导致以5.10–7 mg mL-1的剂量将其以1 mL / 100 g b.wt.的剂量施用于大鼠）对小鼠的腹部收缩产生了76％的抑制和舔在炎症期，大鼠注射爪子的数量增加了70％。因此，没有发现超出法国药典标准的粪便污染细菌，酵母和霉菌。此外，在5000 mg kg-1的剂量下，没有记录到失聪大鼠。结论：“ Sarenta”具有止痛和潜在的抗炎特性，其微生物学性质符合法国药典标准，并且不含急性毒性物质。因此，这项有关草药制剂的首次科学研究可以促进科特迪瓦传统保健人员的知识和专业实践。

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