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首页> 外文期刊>Infectious diseases in obstetrics and gynecology >Determinants of Incident Vulvovaginal Candidiasis inHuman Immunodeficiency Virus-Positive Women
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Determinants of Incident Vulvovaginal Candidiasis inHuman Immunodeficiency Virus-Positive Women

机译：影响人类免疫缺陷病毒阳性妇女的外阴念珠菌病的决定因素

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Objective:Mucosal infections including vulvovaginal candidiasis are a common problem for womenwith human immunodeficiency virus (HIV) infection. Our objective was to determine which factorspredict the development of symptomatic disease among HIV-infected women.Materials and Methods:In a prospective study from 1991 to 1995, 205 HIV-positive women wereevaluated every 6 months for occurrences of vulvovaginal candidiasis. Included in the study wereall initially asymptomatic women, whether they were fungal-culture-positive or -negative at baseline.Excluded from the study were all women with symptomatic vulvovaginal candidiasis at theinitial visit, those who developed trichomonas vaginitis at any visit, and those who used any antifungalagents.Results:The risk of the development of vulvovaginal candidiasis did not differ between womenwho were asymptomatically colonized at baseline and those who were fungal-culture-negative.However, the risk of developing vulvovaginal candidiasis was increased 6.8 times for women withCD4 counts less than 200 cells/mm3at baseline.Conclusions:Fungal culture is not predictive of the development of symptomatic vulvovaginalcandidiasis. Women infected with HIV who have CD4 counts below 200 cells/mm3should bemonitored more carefully for vulvovaginal candidiasis. Infect. Dis. Obstet. Gynecol. 8:176–180,2000.
机译：目的：包括念珠菌性阴道阴道炎在内的粘膜感染是人类免疫缺陷病毒（HIV）感染妇女的常见问题。我们的目标是确定哪些因素可以预测HIV感染女性的症状性疾病的发展。材料与方法：在1991年至1995年的一项前瞻性研究中，每6个月对205位HIV阳性女性进行外阴阴道念珠菌病的发生评估。这项研究包括所有最初无症状的妇女，无论是在基线时是真菌培养阳性还是阴性的妇女。这项研究排除了所有在初次就诊时都患有有症状性阴道念珠菌病的妇女，在任何就诊时都患有滴虫性阴道炎的妇女以及结果：基线无症状定植的女性和真菌培养阴性女性的念珠菌性阴道阴道念珠菌病的发展风险没有差异，但是CD4计数女性的念珠菌性阴道念珠菌病的患病风险增加了6.8倍。结论：真菌培养不能预示有症状的外阴阴道念珠菌病的发展。 CD4计数低于200细胞/ mm3的HIV感染妇女应更仔细地监测是否存在念珠菌性阴道念珠菌病。感染。 Dis。 Obstet。 Gynecol。 8：176-180,2000。

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