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首页> 外文期刊>International Journal of Pharmacology >In vitro Anticancer, Antioxidant and Antimicrobial Activities of Crude Methanolic Extract of Euphorbia cactus Ehrenb Plant
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In vitro Anticancer, Antioxidant and Antimicrobial Activities of Crude Methanolic Extract of Euphorbia cactus Ehrenb Plant

机译：一品红仙人掌粗甲醇提取物的体外抗癌，抗氧化性和抗菌活性。

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Background and Objective: Euphorbiaceae is a wide spread family of genus Euphorbia , from that family, belongs more than 2000 species. The plants of this genus have been used for a long time in traditional medicine. The present investigation is focused on the anticancer and antioxidant potential and antimicrobial activity of the m ethanolic extract of Euphorbia cactus Ehrenb plant ( E. cactus Ehrenb). Materials and Methods: The study was facilitated by collecting the plant sample and subjected to crude methanol extraction. The anticancer activity was examined by MTT assay against three cancer cell lines MCF-7, PC-3 and HEPG2. The antimicrobial activity was determined using the agar diffusion method and MIC-determination. The DPPH radical method was used for the determination of antioxidant activity . Results: Interesting cytotoxic activity was observed for the extract against MCF-7 cell line compared to the known anticancer drugs. The antioxidant activity of the extract showed highly inhibitory activity compared with ascorbic acid . In addition, the m ethanolic extract showed the highest activity against Gram-positive bacteria, Bacillus subtilis and Streptococcus pneumonia and Gram-negative bacteria, Escherichia coli , compared with the standard drug. The extract didn’t exert any activity against the pathogenic yeast species ( Candida albicans ) under these screening conditions. Conclusion: The current study demonstrated for the first time that E. cactus Ehrenb m ethanolic extract has anticancer effects against cancer cells from 3 types of cancerous cell lines. This may be a promising finding for future cancer treatments and in the prevention of cancer using natural products.
机译：背景与目的：大戟科（Euphorbiaceae）是大戟属（Euphorbia）的一个广泛传播的家族，隶属于2000多个物种。该属植物已在传统医学中使用了很长时间。本研究侧重于大戟仙人掌Ehrenb植物（E. cactus Ehrenb）的乙醇提取物的抗癌和抗氧化潜力以及抗菌活性。材料和方法：通过收集植物样品并进行粗甲醇萃取来促进研究。通过MTT测定法检测了对三种癌细胞系MCF-7，PC-3和HEPG2的抗癌活性。使用琼脂扩散法和MIC-测定法确定抗微生物活性。用DPPH自由基法测定抗氧化活性。结果：与已知的抗癌药相比，提取物针对MCF-7细胞系观察到了有趣的细胞毒性活性。与抗坏血酸相比，提取物的抗氧化活性具有较高的抑制作用。此外，与标准药物相比，乙醇提取物对革兰氏阳性菌，枯草芽孢杆菌和肺炎链球菌以及革兰氏阴性菌大肠杆菌表现出最高的活性。在这些筛选条件下，提取物对病原酵母菌（白色念珠菌）没有任何活性。结论：目前的研究首次证明仙人掌仙人掌乙醇提取物对三种类型癌细胞系的癌细胞具有抗癌作用。对于将来的癌症治疗以及使用天然产物预防癌症，这可能是一个有希望的发现。

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