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首页> 外文期刊>Infectious diseases in obstetrics and gynecology >Detection of Human Papillomavirus DNA by AffiProbe HPV-DNA Test Kit in Cervical Scrapes orBiopsies-Histopathologic Correlates
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Detection of Human Papillomavirus DNA by AffiProbe HPV-DNA Test Kit in Cervical Scrapes orBiopsies-Histopathologic Correlates

机译：通过宫颈癌或活检组织病理相关性的AffiProbe HPV-DNA检测试剂盒检测人乳头瘤病毒DNA

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Objective:The aim of this study was to evaluate and compare the efficacy of punch biopsies andcervical scrapes in the detection of human papillomavirus (HPV) DNA from the cervix and compare the results with thehistopathologic diagnosis.Methods:The specimens were collected simultaneously, and HPV DNA was detected using aliquid hybridization test.Results:Biopsies and scrapes were equally efficient, but each detected only two-thirds of allHPV-DNA-positive patients. Thus, the positivity rate increased when both tests were used. Overall, 13% of patients with normal histopathology, 38% of patients with benign atypia, and 66% of patients with squamous intraepithelial lesions (SIL) were HPV-DNA positive. HPV-DNA 16 was found in 54% of HPV-DNA-positive patients with SIL, in 20% of HPV-DNA-positive patients with atypia, and in none of patients with normal histopathology.Conclusions:The liquid hybridization test used in this study detects HPV DNA equally efficientlyfrom both biopsies and scrapes. The test can be performed in 1 working day. However, the sensitivity of the test is low, and it only detects a limited number of HPV types.
机译：目的：本研究的目的是评估和比较穿孔活检和宫颈刮片在宫颈中检测人乳头瘤病毒（HPV）DNA的功效，并将结果与​​组织病理学诊断进行比较。方法：同时收集标本和HPV结果：活组织检查和刮擦法同样有效，但每例仅检测出三分之二的HPV-DNA阳性患者。因此，当同时使用两种测试时，阳性率增加。总体而言，13％的组织病理学正常的患者，38％的良性异型患者和66％的鳞状上皮内病变（SIL）患者均为HPV-DNA阳性。在54％的SIL的HPV-DNA阳性患者，20％的非典型性HPV-DNA阳性患者以及没有组织病理学正常的患者中均发现了HPV-DNA 16。研究从活组织检查和刮擦中同样有效地检测到HPV DNA。该测试可以在1个工作日内完成。但是，该测试的灵敏度很低，并且只能检测到有限数量的HPV类型。

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