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首页> 外文期刊>Infectious Diseases of Poverty >Acquired immunity and asymptomatic reservoir impact on frontline and airport ebola outbreak syndromic surveillance and response
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Acquired immunity and asymptomatic reservoir impact on frontline and airport ebola outbreak syndromic surveillance and response

机译：获得性免疫力和无症状水库对一线和机场埃博拉暴发症状的监测和反应的影响

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The number of surveillance networks for infectious disease diagnosis and response has been growing. In 2000, the World Health Organization (WHO) established the Global Outbreak Alert and Response Network, which has been endorsed by each of the 46 WHO African members since then. Yet, taming the dynamics and plague of the vicious Ebola virus disease (EVD) in African countries has been patchy and erratic due to inadequate surveillance and contact tracing, community defiance and resistance, a lack of detection and response systems, meager/weak knowledge and information on the disease, inadequacies in protective materials protocols, contact tracing nightmare and differing priorities at various levels of the public health system. Despite the widespread acceptance of syndromic surveillance (SS) systems, their ability to provide early warning alerts and notifications of outbreaks is still unverified. Information is often too limited for any outbreak, or emerging or otherwise unexpected disease, to be recognized at either the community or the national level. Indeed, little is known about the role and the interactions between the Ebola infection and exposure to other syndemics and the development of acquired immunity, asymptomatic reservoir, and Ebola seroconversion. Can lessons be learnt from smallpox, polio, and influenza immunity, and can immunization against these serve as a guide? In most endemic countries, community health centers and disease control and prevention at airports solely relies on passive routine immunization control and reactive syndromic response. The frontline and airport Ebola SS systems in West Africa have shown deficiencies in terms of responding with an alarming number of case fatalities, and suggest that more detailed insights into Ebola, and proactive actions, are needed. The quest for effective early indicators (EEE) in shifting the public and global health paradigm requires the development and implementation of a comprehensive and effective community or regional integrated pandemic preparedness and surveillance response systems tailored to local contexts. These systems must have mechanisms for early identification, rapid contact tracing and tracking, confirmation, and communication with the local population and the global community, and must endeavor to respond in a timely manner.
机译：用于传染病诊断和应对的监视网络的数量正在增长。 2000年，世界卫生组织（世卫组织）建立了全球疫情警报和反应网络，此后得到世卫组织46个非洲成员的认可。然而，由于监视和接触者追踪不足，社区的反抗和抵抗，缺乏检测和响应系统，知识薄弱/知识不足，在非洲国家驯服恶性埃博拉病毒病（EVD）的动态和瘟疫是零星的和不稳定的。有关疾病的信息，防护材料规程的不足，接触者追踪的噩梦以及公共卫生系统各个级别上的不同优先事项。尽管症状监测（SS）系统已被广泛接受，但是它们提供预警警报和爆发通知的能力仍未得到验证。对于社区或国家一级无法识别的任何暴发，新发疾病或其他意外疾病，信息通常太有限。的确，关于埃博拉病毒感染和暴露于其他综合症的作用以及获得性免疫，无症状性水库和埃博拉血清转化的发生之间的作用和相互作用知之甚少。可以从天花，脊髓灰质炎和流感免疫中吸取经验教训，针对这些免疫接种是否可以作为指导？在大多数流行国家，社区卫生中心以及机场的疾病控制和预防仅依赖于被动的常规免疫控制和反应性综合症状。西非的前线和机场埃博拉SS系统在应对令人震惊的死亡人数方面显示出不足，并建议需要对埃博拉病毒有更详细的了解并采取积极行动。在转变公共和全球卫生范式中寻求有效的早期指标（EEE）要求开发和实施针对当地情况的全面有效的社区或区域综合性大流行防备和监视应对系统。这些系统必须具有早期识别，快速联系人追踪和跟踪，确认以及与当地居民和全球社区沟通的机制，并且必须努力及时做出响应。

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