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首页> 外文期刊>International Journal of Research in Medical Sciences >Correlation between microalbuminuria and glycosylated haemoglobin and cardiovascular disease in diabetic patients: a case-control study
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Correlation between microalbuminuria and glycosylated haemoglobin and cardiovascular disease in diabetic patients: a case-control study

机译：糖尿病患者微量白蛋白尿与糖基化血红蛋白与心血管疾病的相关性：病例对照研究

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Background: Microalbuminuria is an independent risk factor for cardiovascular mortality in both diabetic and non-diabetic individuals. Our aim was to assess the incidence of elevated glycosylated haemoglobin and cardiovascular disease in relation to microalbuminuria in diabetic patients. Methods: Diabetic patients with or without microalbuminuria were assigned into two groups. Each group consisted of 100 patients. Patients with co-morbid conditions which contribute to microalbuminuria were excluded from this study. Data on clinical features, fasting and postprandial blood glucose, HbA1C (glycosylated haemoglobin) level, urine microalbumin levels, renal parameters, cardiovascular events, diabetic retinopathy changes were collected for both groups and compared. Results: Majority of patients were in 5th and 6th decade with male to female ratio of 2.5:1 in microalbuminuria group and 1:1.1 in non-microalbuminuria group. Mean duration of diabetes was 4.3 yrs in patients with microalbuminuria; and 3.5 yrs in patients without microalbuminuria. Incidence of elevated glycosylated haemoglobin (HbA1c ≥ 6.5%) in microalbuminuria group was 69%; in patients without microalbuminuria was 43%. Incidence of coronary artery disease (CAD) was 32% in microalbuminuria group; 16% in patients without microalbuminuria. These differences were statistically significant. Diabetic retinopathy was observed in 23% of patients in microalbuminuria group; 19% in patients without microalbuminuria. Conclusions: Microalbuminuria in diabetic patients was significantly associated with poor glycaemic control. It was strongly associated with longer duration of diabetes. Incidence of cardiovascular events was higher in patients with microalbuminuria compared to patients without microalbuminuria.
机译：背景：微量蛋白尿是糖尿病和非糖尿病患者心血管死亡的独立危险因素。我们的目的是评估与糖尿病患者微量白蛋白尿有关的糖基化血红蛋白升高和心血管疾病的发生率。方法：将有或无微量白蛋白尿的糖尿病患者分为两组。每组由100名患者组成。患有微量白蛋白尿的合并症患者被排除在本研究之外。两组均收集有关临床特征，禁食和餐后血糖，HbA1C（糖基化血红蛋白）水平，尿微量白蛋白水平，肾脏参数，心血管事件，糖尿病性视网膜病变变化的数据。结果：微白蛋白尿组的患者多数在第5和第6个十年，男女比例为2.5：1，非微白蛋白尿组的男女比例为1：1.1。微量白蛋白尿患者的平均糖尿病病程为4.3岁;无微量白蛋白尿的患者为3.5岁。微量白蛋白尿组糖化血红蛋白升高（HbA1c≥6.5％）的发生率为69％;无微量白蛋白尿的患者为43％。微量白蛋白尿组的冠状动脉疾病（CAD）发生率为32％。无微量白蛋白尿的患者为16％。这些差异具有统计学意义。微量白蛋白尿组23％的患者出现糖尿病性视网膜病变。无微量白蛋白尿的患者为19％。结论：糖尿病患者微量白蛋白尿与血糖控制不良有关。它与糖尿病持续时间长有关。与无微量白蛋白尿的患者相比，有微量白蛋白尿的患者的心血管事件发生率更高。

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