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首页> 外文期刊>International Journal of Research in Medical Sciences >Evaluation of thickness of retinal nerve fiber layer and ganglion cell layer with inner plexiform layer in patients without diabetic retinopathy and mild diabetic retinopathy in type 2 diabetes mellitus patients using spectral-domain optical coherence tomography
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Evaluation of thickness of retinal nerve fiber layer and ganglion cell layer with inner plexiform layer in patients without diabetic retinopathy and mild diabetic retinopathy in type 2 diabetes mellitus patients using spectral-domain optical coherence tomography

机译：应用光谱域光学相干断层扫描技术评估2型糖尿病无糖尿病视网膜病变和轻度糖尿病视网膜病变的患者视网膜神经纤维层和神经内膜层的厚度

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Background: A widely accepted pathogenesis of DR consists of microvascular abnormalities. However recent investigations have demonstrated neurodegenerative alterations before the appearance of microvascular changes in patients with DM. Aim of the study was to evaluate thickness of retinal nerve fiber layer and ganglion cell layer with inner plexiform layer in patent without diabetic retinopathy and mild diabetic retinopathy in type 2 diabetic patients using spectral domain optical coherence tomography. Methods: Thirty patients with type 2 diabetes mellitus without diabetic retinopathy, 30 with mild diabetic retinopathy and 30 healthy controls are taken considering inclusion and exclusion criteria. GCL-ILM and RNFL thickness was measured in each individual and measurements were compared using one way ANOVA test and Pearson’s correlation was performed to evaluate the linear correlation between variables and calculated p value <0.05 was regarded as significant. Results: The average RNFL thickness was 86.18±8.44μm and 91.79±4.77μm in diabetic patients and controls respectively (p=0.002). Furthermore, for two different groups of diabetic patients, the average RNFL thickness was 86.74±11.18μm in the no DR group and 85.62±11.10μm in the mild DR group (p=0.697). The average GCL-IPL thickness was 79.95±4.32μm and 84.66±3.26μm in diabetic patients and controls, respectively (p=<0.001). Furthermore, for two different groups of diabetic patients, the average GCL-IPL thickness was 80.15±5.78μm in the no DR group and 79.75±5.70μm in the mild DR group (p=0.788). Conclusions: There was a statistically signi?cant reduction of the mean GCL-IPL and RNFL thickness in type 2 diabetic patients with no or mild DR compared with a homogenous control group indicating neuroretinal changes occur before vascular changes of diabetic retinopathy. But the correlation of average RNFL thickness and GCL-IPL thickness was not statistically significant with the duration of diabetes and HbA1c value.
机译：背景：DR的广泛接受的发病机制包括微血管异常。但是，最近的研究表明，DM患者出现微血管改变之前会发生神经退行性改变。该研究的目的是使用光谱域光学相干断层扫描技术评估2型糖尿病患者无糖尿病视网膜病变和轻度糖尿病视网膜病变的患者视网膜神经纤维层和具有内丛状层的神经节细胞层的厚度。方法：考虑纳入和排除标准，选取30例无糖尿病性视网膜病变的2型糖尿病，30例轻度糖尿病性视网膜病变和30名健康对照者。测量每个人的GCL-ILM和RNFL厚度，并使用一种方差分析检验比较测量结果，并通过Pearson相关性评估变量之间的线性相关性，计算出的p值<0.05被认为是显着的。结果：糖尿病患者和对照组的平均RNFL厚度分别为86.18±8.44μm和91.79±4.77μm（p = 0.002）。此外，对于两组不同的糖尿病患者，无DR组的平均RNFL厚度为86.74±11.18μm，轻度DR组的平均RNFL厚度为85.62±11.10μm（p = 0.697）。糖尿病患者和对照组的平均GCL-IPL厚度分别为79.95±4.32μm和84.66±3.26μm（p = <0.001）。此外，对于两组不同的糖尿病患者，无DR组的平均GCL-IPL厚度为80.15±5.78μm，轻度DR组的平均GCL-IPL厚度为79.75±5.70μm（p = 0.788）。结论：与同质对照组相比，无或轻度DR的2型糖尿病患者的平均GCL-IPL和RNFL厚度有统计学意义的降低，这表明在糖尿病性视网膜病变的血管改变之前发生了神经视网膜改变。但是，平均RNFL厚度和GCL-IPL厚度的相关性与糖尿病持续时间和HbA1c值之间无统计学意义。

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