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首页> 外文期刊>International Journal of Research in Medical Sciences >Result and outcome of shorter fractionation schedule for post-operative cancer breast patients
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Result and outcome of shorter fractionation schedule for post-operative cancer breast patients

机译：乳腺癌术后分馏方案缩短的结果和结果

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Background: The purpose of this prospective study is to determine the effectiveness and cosmetic outcome of shorter fractionated radiotherapy in post-operative invasive breast cancer patients. Methods: Between July 2009 and June 2011, 216 post-operative cancer breast patients were treated with this regimen on cobalt60. The chest wall and supraclavicular area were treated using a tangential parallel pair, & direct supraclavicular portal with wedges as necessary, to a dose of 40 Gy / 15 fractions (study group) (133 cGy for tangential and 266 cGy for supraclavicular field each). (Control Group received 50 Gy / 25#) No additional boost was given. The median duration of follow-up surviving patients are 3 years. Results: From July 2009 to July 2011 (2 years), 216 histopathologically proven cases of Invasive ductal carcinoma of Breast were included in this study. All patients with early and locally advanced stage breast cancer were treated with hypofractionated and conventional schedule of radiotherapy. At baseline 80.19% in the study and 75.45% of patients in the control group were being rated as excellent or good. At 2 years, the percentages of patients with an excellent or good cosmetic outcome were 75.80% in the study and 73% in the control group. Grade II skin reactions were more in control (60%) as compared to study group (49%). A radiation schedule delivering 40 Gy / 15 # seems to offer control rates of locoregional tumour relapse & late adverse effects at least as favourable as the standard schedule of 50 Gy / 25#. Conclusion: Shorter fractionation schedule is very much effective in preventing recurrent breast cancer and it provides a high level of patient satisfaction as well as reduce money and overall treatment time. Its shorter duration offers the added advantage of a more efficient use of resources and greater patient convenience.
机译：背景：这项前瞻性研究的目的是确定较短的分次放疗在术后浸润性乳腺癌患者中的有效性和美容效果。方法：在2009年7月至2011年6月之间，采用Cobalt60方案治疗了216名术后乳腺癌患者。使用切线平行对治疗胸壁和锁骨上区域，必要时使用楔形直接锁骨上锁骨上门治疗剂量为40 Gy / 15分数（研究组）（切线为133 cGy，锁骨上区域为266 cGy）。 （控制组收到50 Gy / 25＃）没有提供额外的提升。随访幸存患者的中位时间为3年。结果：从2009年7月至2011年7月（2年），该研究包括了216例经组织病理学证实的乳腺浸润性导管癌病例。所有患有早期和局部晚期乳腺癌的患者均采用常规的放疗方案治疗。在研究中，基线时80.19％和对照组中75.45％的患者被评为优或良。在2年时，该研究中具有优异或良好美容效果的患者百分比在研究中为75.80％，在对照组中为73％。与研究组（49％）相比，对照组（60％）的II级皮肤反应更高。提供40 Gy / 15＃的放疗时间表似乎可以控制局部肿瘤的复发率和晚期不良反应至少与50 Gy / 25＃的标准时间表一样好。结论：更短的分级计划对预防复发性乳腺癌非常有效，它可以使患者满意，并减少金钱和总体治疗时间。它的持续时间较短，提供了更多优势，可以更有效地利用资源并为患者带来更大的便利。

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